Research workbench
AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q00959)
Analyse AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q00959
- Type
- protein
- Length
- 1,464 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x1bC4517e06e9f0cB40EF3CB193a013Ea75f77bf6
- Molecule
- Glutamate receptor ionotropic, NMDA 2A
- UniProt
- Q00959
- Pockets
- 15 · best druggability 0.72
Structure
1 distinct chain · 23% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor ionotropic, NMDA 2A | protein | 1464 | 23% helix, 10% strand | Q00959 |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 732 | 0.72 | 0.78 | 52 | empty |
| 2 | 312 | 0.70 | 0.83 | 45 | empty |
| 3 | 171 | 0.62 | 0.84 | 35 | empty |
| 4 | 394 | 0.61 | 0.77 | 46 | empty |
| 5 | 151 | 0.49 | 0.78 | 28 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6MM9 · Diheteromeric NMDA receptor GLUN1/GLUN2A in the '1-knuckle' conformation, in complex with… · an experimental structure of the same protein · chain A against D, TM-score 0.51
- 6MM9 · Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with… · an experimental structure of the same protein · chain A against D, TM-score 0.51
- 6MMT · Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2A* in the '1-knuckle' conformation, in… · an experimental structure of the same protein · chain A against D, TM-score 0.51
- 6MMT · Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '1-Knuckle' conformation, in… · an experimental structure of the same protein · chain A against D, TM-score 0.51
- 6MMK · Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with… · an experimental structure of the same protein · chain A against D, TM-score 0.50
- 6MMK · Diheteromeric NMDA receptor GLUN1/GLUN2A in the '1-knuckle' conformation, in complex with… · an experimental structure of the same protein · chain A against D, TM-score 0.50
- 6MMW · Triheteromeric NMDA receptor GLUN1/GLUN2A/GLUN2A* in the '2-knuckle- symmetric'… · an experimental structure of the same protein · chain A against D, TM-score 0.49
- 6MMW · Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric'… · an experimental structure of the same protein · chain A against D, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00959
- Elsewhere: UniProt Q00959 · AlphaFold DB Q00959
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