UniProt Q00959
Glutamate receptor ionotropic, NMDA 2A (Q00959)
Glutamate receptor ionotropic, NMDA 2A (UniProt Q00959): 94 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 882 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q00959
- Protein
- Glutamate receptor ionotropic, NMDA 2A
- Experimental structures
- 94
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 882 · 95 records with a druggable one
Structures
95 records of Q00959 in the MolNFT archive: 94 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2A5S | Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate | x-ray diffraction | A | GLU | 1 (best 0.57) |
| 2A5S | Crystal structure of the NR2A ligand binding core in complex with glutamate | x-ray diffraction | A | GLU | 1 (best 0.57) |
| 2A5T | Crystal Structure Of The NR1/NR2A ligand-binding cores complex | x-ray diffraction | B | GLU | 4 (best 0.77) |
| 2A5T | Crystal structure of the NR1/NR2A ligand-binding cores complex | x-ray diffraction | B | GLU | 4 (best 0.77) |
| 4NF4 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | x-ray diffraction | B | GLU | 4 (best 0.84) |
| 4NF4 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with dcka and glutamate | x-ray diffraction | B | GLU | 4 (best 0.84) |
| 4NF5 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 | x-ray diffraction | B | 2JJ | 2 (best 0.82) |
| 4NF5 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and D-AP5 | x-ray diffraction | B | 2JJ | 2 (best 0.82) |
| 4NF6 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA | x-ray diffraction | B | 2JL | 3 (best 0.78) |
| 4NF6 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and ppda | x-ray diffraction | B | 2JL | 3 (best 0.78) |
| 4NF8 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in… | x-ray diffraction | B | GLU | 4 (best 0.80) |
| 4NF8 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and glutamate in… | x-ray diffraction | B | GLU | 4 (best 0.80) |
| 5DEX | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5E0 | 2 (best 0.80) |
| 5DEX | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5E0 | 2 (best 0.80) |
| 5I56 | Agonist-bound GluN1/GluN2A agonist binding domains with TCN201 | x-ray diffraction | B | GLU, 67P | 4 (best 0.81) |
| 5I56 | Agonist-bound GLUN1/GLUN2A agonist binding domains with TCN201 | x-ray diffraction | B | GLU, 67P | 4 (best 0.81) |
| 5I57 | Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains | x-ray diffraction | B | GLU | 3 (best 0.80) |
| 5I57 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains | x-ray diffraction | B | GLU | 3 (best 0.80) |
| 5I58 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains with mpx-004 | x-ray diffraction | B | GLU, 67R | 5 (best 0.78) |
| 5I58 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains with mpx-004 | x-ray diffraction | B | GLU, 67R | 5 (best 0.78) |
| 5I59 | Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 | x-ray diffraction | B | GLU, 67Q | 4 (best 0.80) |
| 5I59 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains with mpx 007 | x-ray diffraction | B | GLU, 67Q | 4 (best 0.80) |
| 5JTY | Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007 | x-ray diffraction | B | 6ND, GLU | 5 (best 0.84) |
| 5JTY | Glutamate- and dcka-bound GLUN1/GLUN2A agonist binding domains with mpx-007 | x-ray diffraction | B | 6ND, GLU | 5 (best 0.84) |
| 5TPW | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in… | x-ray diffraction | B | ZN, SO4 | 5 (best 0.75) |
| 5TPW | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2A in… | x-ray diffraction | B | ZN, SO4 | 5 (best 0.75) |
| 5TQ0 | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2A in the… | x-ray diffraction | B | SO4 | 6 (best 0.78) |
| 5TQ2 | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in… | x-ray diffraction | B | ZN, SO4 | 8 (best 0.72) |
| 5TQ2 | Crystal structure of amino terminal domains of the NMDA receptor subunit GLUN1 and GLUN2A in… | x-ray diffraction | B | ZN, SO4 | 8 (best 0.72) |
| 5VIH | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DZ | 2 (best 0.80) |
| 5VIH | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DZ | 2 (best 0.80) |
| 5VII | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DY | 2 (best 0.80) |
| 5VII | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DY | 2 (best 0.80) |
| 5VIJ | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DX | 2 (best 0.81) |
| 5VIJ | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | B | 5DX | 2 (best 0.81) |
| 6MM9 | Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 20 (best 0.89) |
| 6MM9 | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '1-knuckle' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 20 (best 0.89) |
| 6MMA | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 17 (best 0.89) |
| 6MMA | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'extended' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 17 (best 0.89) |
| 6MMB | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with… | electron microscopy | B, D | NAG | 20 (best 0.85) |
| 6MMB | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'super-splayed' conformation, in complex with… | electron microscopy | B, D | NAG | 20 (best 0.85) |
| 6MMG | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 18 (best 0.88) |
| 6MMG | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '2-knuckle-symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 18 (best 0.88) |
| 6MMH | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-2' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 16 (best 0.87) |
| 6MMH | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'extended-2' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 16 (best 0.87) |
| 6MMI | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Splayed-Open' conformation, in complex with… | electron microscopy | B, D | NAG | 14 (best 0.89) |
| 6MMI | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'splayed-open' conformation, in complex with… | electron microscopy | B, D | NAG | 14 (best 0.89) |
| 6MMJ | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with… | electron microscopy | B, D | NAG | 14 (best 0.87) |
| 6MMJ | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'super-splayed' conformation, in complex with… | electron microscopy | B, D | NAG | 14 (best 0.87) |
| 6MMK | Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 20 (best 0.89) |
| 6MMK | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '1-knuckle' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 20 (best 0.89) |
| 6MML | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex… | electron microscopy | B, D | NAG | 17 (best 0.89) |
| 6MML | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '2-knuckle-asymmetric' conformation, in complex… | electron microscopy | B, D | NAG | 17 (best 0.89) |
| 6MMM | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-1' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 17 (best 0.88) |
| 6MMM | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'extended-1' conformation, in complex with glycine… | electron microscopy | B, D | NAG | 17 (best 0.88) |
| 6MMN | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 18 (best 0.86) |
| 6MMN | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '2-knuckle-symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 18 (best 0.86) |
| 6MMP | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 16 (best 0.87) |
| 6MMP | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '2-knuckle-symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 16 (best 0.87) |
| 6MMR | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with… | electron microscopy | B, D | NAG | 17 (best 0.87) |
35 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 38 records
- GLU · Glutamic acid · in 22 records
- SO4 · Sulfate ion · in 5 records
- QM1 · 3-(carboxymethyl)pyridine-2-carboxylic acid · in 4 records
- QM4 · (2S,3R)-1-[7-(2-carboxyethyl)phenanthrene-2-carbonyl]piperazine-2,3-dicarboxylic acid · in 4 records
- ZN · Zinc ion · in 4 records
- 2JJ · 5-phosphono-D-norvaline · in 2 records
- 2JL · (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid · in 2 records
- 5DX · 5-[(2R)-2-amino-2-carboxyethyl]-1-(4-bromophenyl)-1H-pyrazole-3-carboxylic acid · in 2 records
- 5DY · 5-[(2R)-2-amino-2-carboxyethyl]-1-[4-(3-fluoropropyl) phenyl]-1H-pyrazole-3-carboxylic acid · in 2 records
- 5DZ · 5-[(2R)-2-amino-2-carboxyethyl]-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid · in 2 records
- 5E0 · 5-[(2R)-2-amino-2-carboxyethyl]-1-phenyl-1H-pyrazole-3-carboxylic acid · in 2 records
- 67P · N-({4-[2-(benzenecarbonyl)hydrazinecarbonyl]phenyl}methyl)-3-chloro-4-fluorobenzene-1-sulfonamide · in 2 records
- 67Q · 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide · in 2 records
- 67R · 5-({[(3-chloro-4-fluorophenyl)sulfonyl]amino}methyl)-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide · in 2 records
- 6ND · 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide · in 2 records
- M7V · (1S,2R)-2-[(S)-amino(carboxy)methyl]-1-butylcyclopropane-1-carboxylic acid · in 2 records
- N9A · (3S,5S)-5-[(2R)-2-amino-2-carboxyethyl]-1-(3-ethylphenyl)pyrazolidine-3-carboxylic acid · in 2 records
- N9D · (3R,5S)-5-[(2R)-2-amino-2-carboxyethyl]-1-(4-propylphenyl)pyrazolidine-3-carboxylic acid · in 2 records
- QGP · (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid · in 2 records
Experiment against prediction
- 5I57 chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.94 Å
- 5I57 chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.94 Å
- 6UZR chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.96 Å
- 6UZR chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.96 Å
- 6UZG chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.97 Å
- 6UZG chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.97 Å
- 5I56 chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.97 Å
- 5I56 chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.97 Å
- 2A5T chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.98 Å
- 2A5T chain B against the predicted model Q00959: TM-score 0.98, RMSD 0.98 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.