MolNFT v1 · #30659 · protein

Crystal structure of the NR2A ligand binding core in complex with glutamate

2A5S · N-methyl-D-aspartate receptor NMDAR2A subunit: “Crystal structure of the NR2A ligand binding core in complex with glutamate”. X-ray diffraction, 1 ligand (GLU), 1 pocket (best druggability 0.57). MolNFT v1 #30659 on GenesisL1: 3D…

PDB: 2A5S
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N-methyl-D-aspartate receptor NMDAR2A subunit
UniProt: Q00959
Ligands: GLU
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	N-methyl-D-aspartate receptor NMDAR2A subunit	protein	278	33% helix, 25% strand	Q00959

Ligands and binding sites

GLU · Glutamic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	159	0.57	0.82	30	GLU

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2A5S · Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate · the same entry in another collection · chain A against A, TM-score 1.00
Q00959 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q00959) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00959
Elsewhere: RCSB PDB 2A5S · PDBe 2A5S · UniProt Q00959

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.