Research workbench
AlphaFold monomer V2.0 prediction for nicastrin (Q92542)
Analyse AlphaFold monomer V2.0 prediction for nicastrin (Q92542) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q92542
- Type
- protein
- Length
- 709 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6B679B0fcd62D396C5740D9E0017ed0E2D6Ec3c5
- Molecule
- Nicastrin
- UniProt
- Q92542
- Pockets
- 5 · best druggability 0.72
Structure
1 distinct chain · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicastrin | protein | 709 | 37% helix, 18% strand | Q92542 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.72 | 0.99 | 20 | empty |
| 2 | 324 | 0.55 | 0.75 | 40 | empty |
| 3 | 101 | 0.36 | 0.74 | 18 | empty |
| 4 | 61 | 0.30 | 0.74 | 13 | empty |
| 5 | 58 | 0.27 | 0.73 | 18 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 5FN3 · Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN3 · Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5A63 · Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5A63 · Cryo-EM structure of the human gamma-secretase complex at 3.4 ångström resolution. · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 8KCS · Cryo-EM structure of human gamma-secretase in complex with BMS906024 · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN2 · Cryo-EM structure of gamma secretase in complex with a drug DAPT · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN2 · Cryo-EM structure of gamma secretase in complex with a drug dapt · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN5 · Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN5 · Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 8K8E · Human gamma-secretase in complex with a substrate mimetic · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN4 · Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 5FN4 · Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble · an experimental structure of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92542
- Elsewhere: UniProt Q92542 · AlphaFold DB Q92542
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