Research workbench
AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P19838)
Analyse AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P19838
- Type
- protein
- Length
- 968 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbff27Dc0a932A6E0d9Fe883AAbD1BF27bB95A69F
- Molecule
- Nuclear factor nf-kappa-B P105 subunit
- UniProt
- P19838
- Pockets
- 3 · best druggability 0.53
Structure
1 distinct chain · 27% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear factor nf-kappa-B P105 subunit | protein | 968 | 27% helix, 12% strand | P19838 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.53 | 0.74 | 31 | empty |
| 2 | 53 | 0.30 | 0.76 | 16 | empty |
| 3 | 64 | 0.28 | 0.73 | 12 | empty |
Compared structures
- 2O61 · Crystal structure of nfkb, IRF7, IRF3 bound to the interferon-B enhancer · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 2O61 · Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 3GUT · Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 3GUT · Crystal structure of a higher-order complex of P50:RELA bound to the HIV-1 ltr · an experimental structure of the same protein · chain A against B, TM-score 0.32
- 1SVC · Nfkb P50 homodimer bound to DNA · an experimental structure of the same protein · chain A against P, TM-score 0.32
- 1SVC · Nfkb P50 homodimer bound to DNA · an experimental structure of the same protein · chain A against P, TM-score 0.32
- 8TQD · NF-Kappa-B1 Bound with a Covalent Inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.20
- 1NFI · I-kappa-B-ALPHA/NF-kappa-B complex · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 1NFI · I-kappa-B-ALPHA/NF-kappa-B complex · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 2DBF · Solution structure of the death domain in human nuclear factor nf- kappa-B P105 subunit · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 2DBF · Solution structure of the Death domain in human Nuclear factor NF-kappa-B p105 subunit · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 7LFC · Structure of importin A3 bound to P50 nls · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19838
- Elsewhere: UniProt P19838 · AlphaFold DB P19838
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