Research workbench
AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388)
Analyse AlphaFold monomer V2.0 prediction for NADPH--cytochrome P450 reductase (P00388) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P00388
- Type
- protein
- Length
- 678 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd91633319BDB0a92cbC4f08DeA734Bf74C030064
- Molecule
- NADPH--cytochrome P450 reductase
- UniProt
- P00388
- Pockets
- 5 · best druggability 0.84
Structure
1 distinct chain · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADPH--cytochrome P450 reductase | protein | 678 | 36% helix, 19% strand | P00388 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 665 | 0.84 | 0.88 | 83 | empty |
| 2 | 426 | 0.79 | 0.87 | 61 | empty |
| 3 | 197 | 0.55 | 0.79 | 28 | empty |
| 4 | 89 | 0.45 | 0.80 | 18 | empty |
| 5 | 67 | 0.35 | 0.77 | 14 | empty |
Compared structures
- 1JA1 · CYPOR-Triple Mutant · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 1JA1 · Cypor-triple mutant · an experimental structure of the same protein · chain A against A, TM-score 0.91
- 4YAW · Reduced CYPOR mutant - G141del · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4YAW · Reduced cypor mutant - G141DEL · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 1J9Z · CYPOR-W677G · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 1J9Z · CYPOR-W677G · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4Y7C · Rat cypor mutant - G141DEL/E142N · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4Y7C · rat CYPOR mutant - G141del/E142N · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 5URI · Rat CYPOR/D632A with 2'-AMP · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 5URI · Rat CYPOR/D632A with 2'-AMP · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4YAF · Rat cypor with 2'-AMP · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4YAF · rat CYPOR with 2'-AMP · an experimental structure of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00388
- Elsewhere: UniProt P00388 · AlphaFold DB P00388
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