Research workbench
AlphaFold monomer V2.0 prediction for methylenetetrahydrofolate dehydrogenase [NAD(+)] (Q02046)
Analyse AlphaFold monomer V2.0 prediction for methylenetetrahydrofolate dehydrogenase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q02046
- Type
- protein
- Length
- 320 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xDB1B87D3D3e7F975C31C76E78e19615Bb4ABF1ec
- Molecule
- Methylenetetrahydrofolate dehydrogenase [NAD(+)]
- UniProt
- Q02046
- Pockets
- 5 · best druggability 0.73
Structure
1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | protein | 320 | 41% helix, 18% strand | Q02046 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.73 | 0.80 | 51 | empty |
| 2 | 225 | 0.67 | 0.85 | 25 | empty |
| 3 | 59 | 0.31 | 0.76 | 10 | empty |
| 4 | 52 | 0.28 | 0.75 | 13 | empty |
| 5 | 52 | 0.26 | 0.73 | 12 | empty |
Compared structures
- 1EE9 · Crystal structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from… · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 1EE9 · Crystal structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from… · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 1EDZ · Structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from… · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 1EDZ · Structure of the NAD-dependent 5,10- methylenetetrahydrofolate dehydrogenase from… · an experimental structure of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02046
- Elsewhere: UniProt Q02046 · AlphaFold DB Q02046
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