MolNFT v1 · #5310 · protein

Structure of the NAD-dependent 5,10- methylenetetrahydrofolate dehydrogenase from saccharomyces cerevisiae

1EDZ · 5,10-methylenetetrahydrofolate dehydrogenase: “Structure of the NAD-dependent 5,10- methylenetetrahydrofolate dehydrogenase from saccharomyces cerevisiae”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #5310 on…

PDB: 1EDZ
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5,10-methylenetetrahydrofolate dehydrogenase
EC: 1.5.1.15
UniProt: Q02046
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5,10-methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15)	protein	317	38% helix, 19% strand	Q02046

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	467	0.74	0.82	45	empty
2	280	0.58	0.78	27	empty
3	53	0.32	0.77	10	empty

Compared structures

1EDZ · Structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from… · the same entry in another collection · chain A against A, TM-score 1.00
Q02046 · AlphaFold monomer V2.0 prediction for methylenetetrahydrofolate dehydrogenase [NAD(+)]… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02046
Elsewhere: RCSB PDB 1EDZ · PDBe 1EDZ · UniProt Q02046

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