Research workbench
AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 6 (P52564)
Analyse AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P52564
- Type
- protein
- Length
- 334 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xD8F3D068a9DC758Bf81Ccd312cF842A9701dc5a7
- Molecule
- Dual specificity mitogen-activated protein kinase kinase 6
- UniProt
- P52564
- Pockets
- 3 · best druggability 0.70
Structure
1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity mitogen-activated protein kinase kinase 6 | protein | 334 | 40% helix, 18% strand | P52564 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 468 | 0.70 | 0.80 | 58 | empty |
| 2 | 81 | 0.37 | 0.76 | 16 | empty |
| 3 | 54 | 0.28 | 0.74 | 14 | empty |
Compared structures
- 3VN9 · Rifined crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 3VN9 · Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 8P7J · Crystal structure of MAP2K6 with a covalent compound GCL96 · an experimental structure of the same protein · chain A against B, TM-score 0.76
- 3FME · Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated… · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 3FME · Crystal structure of human mitogen-activated protein kinase kinase 6 (MEK6) activated… · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 8PM3 · Crystal structure of MAP2K6 with a covalent compound GCL94 · an experimental structure of the same protein · chain A against C, TM-score 0.75
- 8A8M · Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6 · an experimental structure of the same protein · chain A against B, TM-score 0.72
- 8A8M · Structure of the MAPK P38ALPHA in complex with its activating MAP2K MKK6 · an experimental structure of the same protein · chain A against B, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52564
- Elsewhere: UniProt P52564 · AlphaFold DB P52564
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