UniProt P52564
Dual specificity mitogen-activated protein kinase kinase 6 (P52564)
Dual specificity mitogen-activated protein kinase kinase 6 (UniProt P52564), EC 2.7.12.2: 13 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, druggability and experiment…
- UniProt
- P52564
- Protein
- Dual specificity mitogen-activated protein kinase kinase 6
- EC
- 2.7.12.2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 24 · 3 records with a druggable one
Structures
14 records of P52564 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y8O | Crystal structure of human p38alpha complexed with a MAPK docking peptide | x-ray diffraction | B | — | — |
| 2Y8O | Crystal structure of human P38ALPHA complexed with a MAPK docking peptide | x-ray diffraction | B | — | — |
| 3ENM | The structure of the MAP2K MEK6 reveals an autoinhibitory dimer | x-ray diffraction | A, B, C, D | — | — |
| 3ENM | The structure of the MAP2K MEK6 reveals an autoinhibitory dimer | x-ray diffraction | A, B, C, D | — | — |
| 3FME | Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant… | x-ray diffraction | A | — | — |
| 3FME | Crystal structure of human mitogen-activated protein kinase kinase 6 (MEK6) activated mutant… | x-ray diffraction | A | — | — |
| 3VN9 | Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state | x-ray diffraction | A | — | — |
| 3VN9 | Rifined crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state | x-ray diffraction | A | — | — |
| 5ETF | Structure of dead kinase MAPK14 with bound the KIM domain of MKK6 | x-ray diffraction | B | — | — |
| 5ETF | Structure of dead kinase MAPK14 with bound the kim domain of MKK6 | x-ray diffraction | B | — | — |
| 8A8M | Structure of the MAPK P38ALPHA in complex with its activating MAP2K MKK6 | electron microscopy | B | AP2, MG | — |
| 8P7J | Crystal structure of MAP2K6 with a covalent compound GCL96 | x-ray diffraction | A, B | X3K | 3 (best 0.65) |
| 8PM3 | Crystal structure of MAP2K6 with a covalent compound GCL94 | x-ray diffraction | A, B, C, D | ZLE | 18 (best 0.80) |
| P52564 | AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase kinase 6… | predicted | A | — | 3 (best 0.70) |
Ligands
Experiment against prediction
- 3FME chain A against the predicted model P52564: TM-score 0.93, RMSD 2.07 Å
- 3FME chain A against the predicted model P52564: TM-score 0.93, RMSD 2.07 Å
- 3VN9 chain A against the predicted model P52564: TM-score 0.91, RMSD 2.32 Å
- 3VN9 chain A against the predicted model P52564: TM-score 0.91, RMSD 2.32 Å
- 8P7J chain B against the predicted model P52564: TM-score 0.91, RMSD 2.31 Å
- 8PM3 chain D against the predicted model P52564: TM-score 0.91, RMSD 2.35 Å
- 8PM3 chain C against the predicted model P52564: TM-score 0.90, RMSD 2.39 Å
- 8P7J chain A against the predicted model P52564: TM-score 0.90, RMSD 2.44 Å
- 8PM3 chain A against the predicted model P52564: TM-score 0.89, RMSD 2.47 Å
- 8PM3 chain B against the predicted model P52564: TM-score 0.89, RMSD 2.49 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.