MolNFT v1 · #63860 · protein
Crystal structure of human mitogen-activated protein kinase kinase 6 (MEK6) activated mutant (S207D, T211D)
3FME · Dual specificity mitogen-activated protein kinase kinase 6: “Crystal structure of human mitogen-activated protein kinase kinase 6 (MEK6) activated mutant (S207D, T211D)”. X-ray diffraction, 1 ligand (STU), 2 pockets (best…
- PDB
- 3FME
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity mitogen-activated protein kinase kinase 6
- EC
- 2.7.12.2
- UniProt
- P52564
- Ligands
- STU
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) | protein | 268 | 44% helix, 17% strand | P52564 |
Ligands and binding sites
- STU · Staurosporine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 560 | 0.69 | 0.78 | 52 | STU |
| 2 | 55 | 0.29 | 0.75 | 14 | empty |
Compared structures
- 3FME · Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated… · the same entry in another collection · chain A against A, TM-score 1.00
- P52564 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52564
- Elsewhere: RCSB PDB 3FME · PDBe 3FME · UniProt P52564
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