Research workbench
AlphaFold monomer V2.0 prediction for integrin beta-3 (O54890)
Analyse AlphaFold monomer V2.0 prediction for integrin beta-3 (O54890) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O54890
- Type
- protein
- Length
- 787 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x576AbE9948fdf53cF041C558443887E553DF5B89
- Molecule
- Integrin beta-3
- UniProt
- O54890
- Pockets
- 3 · best druggability 0.72
Structure
1 distinct chain · 25% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin beta-3 | protein | 787 | 25% helix, 27% strand | O54890 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.72 | 0.78 | 81 | empty |
| 2 | 680 | 0.71 | 0.78 | 69 | empty |
| 3 | 126 | 0.58 | 0.84 | 24 | empty |
Modifications
Observed in the structure: 28 disulfide (disulfide).
Compared structures
- 5XQ1 · Structural basis of kindlin-mediated integrin recognition and activation · an experimental structure of the same protein · chain A against B, TM-score 0.19
- 5XQ1 · Structural basis of kindlin-mediated integrin recognition and activation · an experimental structure of the same protein · chain A against B, TM-score 0.19
- 6VGU · Crystal structure of FERM-folded talin head domain bound to the NPLY motif of… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 6VGU · Crystal structure of ferm-folded talin head domain bound to the nply motif of… · an experimental structure of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O54890
- Elsewhere: UniProt O54890 · AlphaFold DB O54890
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