MolNFT v1 · #139784 · protein
Structural basis of kindlin-mediated integrin recognition and activation
5XQ1 · Fermitin family homolog 2,INTEGRIN beta-3: “Structural basis of kindlin-mediated integrin recognition and activation”. X-ray diffraction, 9 pockets (best druggability 0.79). MolNFT v1 #139784 on GenesisL1: 3D structure, binding…
- PDB
- 5XQ1
- Type
- protein
- Length
- 840 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fermitin family homolog 2,INTEGRIN beta-3
- UniProt
- Q8CIB5, O54890
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fermitin family homolog 2,INTEGRIN beta-3 | protein | 429 | 38% helix, 24% strand | Q8CIB5, O54890 |
| B | Fermitin family homolog 2,INTEGRIN beta-3 | protein | 411 | 39% helix, 24% strand | Q8CIB5, O54890 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 367 | 0.79 | 0.89 | 40 | empty |
| 2 | 392 | 0.76 | 0.86 | 47 | empty |
| 3 | 67 | 0.50 | 0.85 | 15 | empty |
| 4 | 109 | 0.45 | 0.78 | 12 | empty |
| 5 | 100 | 0.38 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2436 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 5XQ1 · Structural basis of kindlin-mediated integrin recognition and activation · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CIB5 · AlphaFold monomer V2.0 prediction for fermitin family homolog 2 (Q8CIB5) · a predicted model of the same protein · chain B against A, TM-score 0.86
- O54890 · AlphaFold monomer V2.0 prediction for integrin beta-3 (O54890) · a predicted model of the same protein · chain B against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CIB5
- Every structure of UniProt O54890
- Elsewhere: RCSB PDB 5XQ1 · PDBe 5XQ1 · UniProt Q8CIB5 · UniProt O54890
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