MolNFT v1 · #167309 · protein
Crystal structure of ferm-folded talin head domain bound to the nply motif of BETA3-integrin
6VGU · Integrin beta-3,TALIN-1: “Crystal structure of ferm-folded talin head domain bound to the nply motif of BETA3-integrin”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #167309 on GenesisL1: 3D structure, binding…
- PDB
- 6VGU
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin beta-3,TALIN-1
- UniProt
- O54890, P26039
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin beta-3,TALIN-1 | protein | 379 | 31% helix, 23% strand | O54890, P26039 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.59 | 0.77 | 40 | empty |
| 2 | 128 | 0.52 | 0.81 | 31 | empty |
| 3 | 82 | 0.39 | 0.78 | 17 | empty |
| 4 | 50 | 0.26 | 0.74 | 14 | empty |
Compared structures
- 6VGU · Crystal structure of FERM-folded talin head domain bound to the NPLY motif of… · the same entry in another collection · chain A against A, TM-score 1.00
- P26039 · AlphaFold monomer V2.0 prediction for talin-1 (P26039) · a predicted model of the same protein · chain A against A, TM-score 0.75
- O54890 · AlphaFold monomer V2.0 prediction for integrin beta-3 (O54890) · a predicted model of the same protein · chain A against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O54890
- Every structure of UniProt P26039
- Elsewhere: RCSB PDB 6VGU · PDBe 6VGU · UniProt O54890 · UniProt P26039
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