Research workbench
AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362)
Analyse AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P11362
- Type
- protein
- Length
- 822 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd91633319BDB0a92cbC4f08DeA734Bf74C030064
- Molecule
- Fibroblast growth factor receptor 1
- UniProt
- P11362
- Pockets
- 5 · best druggability 0.75
Structure
1 distinct chain · 21% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 1 | protein | 822 | 21% helix, 25% strand | P11362 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.75 | 0.78 | 108 | empty |
| 2 | 199 | 0.46 | 0.74 | 22 | empty |
| 3 | 82 | 0.33 | 0.74 | 12 | empty |
| 4 | 67 | 0.29 | 0.73 | 17 | empty |
| 5 | 55 | 0.24 | 0.72 | 13 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3KXX · Structure of the mutant fibroblast growth factor receptor 1 · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 3KXX · Structure of the mutant Fibroblast Growth Factor receptor 1 · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 5FLF · Disease linked mutation in fgfr · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 5FLF · Disease linked mutation in fgfr · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 3GQI · Crystal structure of activated receptor tyrosine kinase in complex with substrates · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 3GQI · Crystal Structure of activated receptor tyrosine kinase in complex with substrates · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 4RWK · Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex… · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 4RWK · Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex… · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 4RWJ · Crystal structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N… · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 4RWJ · Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547… · an experimental structure of the same protein · chain A against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: UniProt P11362 · AlphaFold DB P11362
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