MolNFT v1 · #69690 · protein
Structure of the mutant fibroblast growth factor receptor 1
3KXX · Basic fibroblast growth factor receptor 1: “Structure of the mutant fibroblast growth factor receptor 1”. X-ray diffraction, 18 pockets (best druggability 0.81). MolNFT v1 #69690 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3KXX
- Type
- protein
- Length
- 1,184 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Basic fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P11362
- Pockets
- 18 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 305 | 39% helix, 18% strand | P11362 |
| B | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 305 | 37% helix, 18% strand | P11362 |
| C | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 286 | 36% helix, 17% strand | P11362 |
| D | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 288 | 35% helix, 18% strand | P11362 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1160 | 0.81 | 0.82 | 93 | empty |
| 2 | 1178 | 0.80 | 0.82 | 82 | empty |
| 3 | 316 | 0.64 | 0.80 | 42 | empty |
| 4 | 118 | 0.59 | 0.85 | 21 | empty |
| 5 | 164 | 0.55 | 0.80 | 19 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1716 Ų buried · 27 hydrogen bonds · protein-protein
- A–D · 1685 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 481 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 87 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 23 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3KXX · Structure of the mutant Fibroblast Growth Factor receptor 1 · the same entry in another collection · chain D against D, TM-score 1.00
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 3KXX · PDBe 3KXX · UniProt P11362
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