UniProt Q9Y5Y9
Sodium channel protein type 10 subunit alpha (Q9Y5Y9)
Sodium channel protein type 10 subunit alpha (UniProt Q9Y5Y9): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 96 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9Y5Y9
- Protein
- Sodium channel protein type 10 subunit alpha
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 96 · 5 records with a druggable one
Structures
9 records of Q9Y5Y9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WE4 | Human Nav1.8 with A-803467, class I | electron microscopy | A | NAG, 95T, CLR, PCW, LPE, P5S | 19 (best 0.86) |
| 7WE4 | Sodium channel I | electron microscopy | A | NAG, 95T, CLR, PCW, LPE | — |
| 7WEL | Human Nav1.8 with A-803467, class II | electron microscopy | A | NAG, 95T, CLR, PCW, LPE, P5S | 20 (best 0.86) |
| 7WEL | Sodium channel II | electron microscopy | A | NAG, 95T, CLR, PCW, LPE | — |
| 7WFR | Human Nav1.8 with A-803467, class III | electron microscopy | A | NAG, 95T, CLR, PCW, LPE, P5S | 20 (best 0.85) |
| 7WFR | Sodium channel III | electron microscopy | A | NAG, 95T, CLR, PCW, LPE | — |
| 7WFW | Apo human Nav1.8 | electron microscopy | A | NAG, CLR, PCW, LPE, P5S | 17 (best 0.86) |
| 7WFW | Sodium channel IV | electron microscopy | A | NAG, CLR, PCW, LPE | — |
| Q9Y5Y9 | AlphaFold monomer V2.0 prediction for sodium channel protein type 10 subunit alpha (Q9Y5Y9) | predicted | A | — | 20 (best 0.84) |
Ligands
- CLR · Cholesterol · in 8 records
- LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · in 8 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 8 records
- 95T · 5-(4-chlorophenyl)-~{N}-(3,5-dimethoxyphenyl)furan-2-carboxamide · in 6 records
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 4 records
Experiment against prediction
- 7WFW chain A against the predicted model Q9Y5Y9: TM-score 0.98, RMSD 1.64 Å
- 7WFW chain A against the predicted model Q9Y5Y9: TM-score 0.98, RMSD 1.64 Å
- 7WFR chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.86 Å
- 7WFR chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.86 Å
- 7WE4 chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.96 Å
- 7WEL chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.98 Å
- 7WEL chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.98 Å
- 7WE4 chain A against the predicted model Q9Y5Y9: TM-score 0.97, RMSD 1.96 Å
Elsewhere
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