UniProt Q9Y5N1
Histamine H3 receptor (Q9Y5N1)
Histamine H3 receptor (UniProt Q9Y5N1): 7 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 39 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y5N1
- Protein
- Histamine H3 receptor
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 39 · 8 records with a druggable one
Structures
8 records of Q9Y5N1 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7F61 | Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746 | x-ray diffraction | A | 1IB, CLR | 3 (best 0.76) |
| 8YN5 | Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi | electron microscopy | R | HSM, CLR | 7 (best 0.76) |
| 8YN6 | Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi | electron microscopy | R | ITF, CLR | 4 (best 0.76) |
| 8YN7 | Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo | electron microscopy | R | A1LY2, CLR | 5 (best 0.72) |
| 8YN8 | Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo | electron microscopy | R | A1LY3, CLR | 6 (best 0.78) |
| 8YUU | Cryo-EM structure of the histamine-bound H3R-Gi complex | electron microscopy | R | HSM, CLR | 6 (best 0.72) |
| 8YUV | Cryo-EM structure of the immepip-bound H3R-Gi complex | electron microscopy | R | A1LY4, CLR | 5 (best 0.76) |
| Q9Y5N1 | AlphaFold monomer V2.0 prediction for histamine H3 receptor (Q9Y5N1) | predicted | A | — | 3 (best 0.63) |
Ligands
- CLR · Cholesterol · in 7 records
- HSM · Histamine · in 2 records
- 1IB · N-ethyl-3-fluoranyl-3-[3-fluoranyl-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide · in 1 record
- A1LY2 · 4-(1H-imidazol-4-ylmethyl)pyridine · in 1 record
- A1LY3 · 5-(3-phenylmethoxypropyl)-1H-imidazole · in 1 record
- A1LY4 · 4-(1H-imidazol-5-ylmethyl)piperidine · in 1 record
- ITF · 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate · in 1 record
Experiment against prediction
- 8YN8 chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.13 Å
- 8YN7 chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.12 Å
- 8YUV chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.09 Å
- 8YUU chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.07 Å
- 8YN5 chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.13 Å
- 8YN6 chain R against the predicted model Q9Y5N1: TM-score 0.94, RMSD 2.13 Å
- 7F61 chain A against the predicted model Q9Y5N1: TM-score 0.94, RMSD 1.79 Å
Elsewhere
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