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Ligand · ITF

ITF · 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate

ITF, 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate (C6 H10 N4 S, 170.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
ITF
Formula
C6 H10 N4 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

ITF in 2 structures; the first of them:

  • 7YFD · Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex · ITF R601 · binds ASP94, TYR95, CYS98, THR99, ASN147, GLU182, TRP316, TYR319 and 3 more
  • 8YN6 · Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi · ITF R701 · binds ASP114, TYR115, CYS118, TYR167, GLU206, TRP371, TYR374, THR375 and 3 more

Residues it binds most

TYR 2, TRP 2, ASP 2, CYS 2, GLU 2, PHE 2, THR 2, ASN 1, GLN 1, LEU 1 (residue and the binding sites it lines).

Found with

  • CLR · Cholesterol

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