UniProt Q9Y4E8
Ubiquitin carboxyl-terminal hydrolase 15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (UniProt Q9Y4E8), EC 3.4.19.12: 28 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 74 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y4E8
- Protein
- Ubiquitin carboxyl-terminal hydrolase 15
- EC
- 3.4.19.12
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 74 · 7 records with a druggable one
Structures
29 records of Q9Y4E8 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W6V | Solution structure of the DUSP domain of hUSP15 | solution nmr | A | — | — |
| 1W6V | Solution structure of the dusp domain of HUSP15 | solution nmr | A | — | — |
| 3LMN | Oligomeric structure of the DUSP domain of human USP15 | x-ray diffraction | A, B | — | — |
| 3LMN | Oligomeric structure of the dusp domain of human USP15 | x-ray diffraction | A, B | — | — |
| 3PPA | Structure of the Dusp-Ubl domains of Usp15 | x-ray diffraction | A | — | — |
| 3PPA | Structure of the dusp-ubl domains of USP15 | x-ray diffraction | A | — | — |
| 3PV1 | Crystal structure of the USP15 DUSP-UBL domains | x-ray diffraction | A, B | — | — |
| 3PV1 | Crystal structure of the USP15 dusp-ubl domains | x-ray diffraction | A, B | — | — |
| 3T9L | Structure of N-terminal DUSP-UBL domains of human USP15 | x-ray diffraction | A | — | — |
| 3T9L | Structure of N-terminal dusp-ubl domains of human USP15 | x-ray diffraction | A | — | — |
| 4A3O | Crystal structure of the USP15 DUSP-UBL monomer | x-ray diffraction | A, B | — | — |
| 4A3O | Crystal structure of the USP15 dusp-ubl monomer | x-ray diffraction | A, B | — | — |
| 4A3P | Structure of USP15 DUSP-UBL deletion mutant | x-ray diffraction | A | — | — |
| 4A3P | Structure of USP15 dusp-ubl deletion mutant | x-ray diffraction | A | — | — |
| 5JJW | Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain | x-ray diffraction | B | UNX | 3 (best 0.70) |
| 5JJW | Crystal structure of the hat domain of SART3 in complex with USP15 dusp-ubl domain | x-ray diffraction | B | — | — |
| 6CPM | Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | x-ray diffraction | C, D | CA, ZN, NA | 4 (best 0.80) |
| 6CPM | Structure of the USP15 deubiquitinase domain in complex with a third- generation inhibitory ubv | x-ray diffraction | C, D | CA, ZN, NA | — |
| 6CRN | Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv | x-ray diffraction | A, B, C, D | ZN | 16 (best 0.81) |
| 6CRN | Structure of the USP15 deubiquitinase domain in complex with a high- affinity first-generation ubv | x-ray diffraction | A, B, C, D | ZN | — |
| 6DJ9 | Structure of the USP15 DUSP domain in complex with a high-affinity Ubiquitin Variant (UbV) | x-ray diffraction | A, B, C, D, E, F | — | 19 (best 0.79) |
| 6DJ9 | Structure of the USP15 dusp domain in complex with a high-affinity ubiquitin variant (ubv) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6GH9 | USP15 catalytic domain in complex with small molecule | x-ray diffraction | A, B | ZN, MIX | 9 (best 0.55) |
| 6GH9 | USP15 catalytic domain in complex with small molecule | x-ray diffraction | A, B | ZN, MIX | — |
| 6GHA | USP15 catalytic domain structure | x-ray diffraction | A | ZN | 4 (best 0.38) |
| 6GHA | USP15 catalytic domain structure | x-ray diffraction | A | ZN | — |
| 6ML1 | Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | x-ray diffraction | A, B | CA, ZN, NA, CL | 8 (best 0.80) |
| 6ML1 | Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory ubv | x-ray diffraction | A, B | CA, ZN, NA, CL | — |
| Q9Y4E8 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 15 (Q9Y4E8) | predicted | A | — | 11 (best 0.73) |
Ligands
Experiment against prediction
- 6ML1 chain A against the predicted model Q9Y4E8: TM-score 0.99, RMSD 0.91 Å
- 6ML1 chain A against the predicted model Q9Y4E8: TM-score 0.99, RMSD 0.91 Å
- 6GHA chain A against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.17 Å
- 6GHA chain A against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.17 Å
- 6ML1 chain B against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.22 Å
- 6ML1 chain B against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.22 Å
- 6GH9 chain B against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.32 Å
- 6GH9 chain B against the predicted model Q9Y4E8: TM-score 0.98, RMSD 1.32 Å
- 6CPM chain D against the predicted model Q9Y4E8: TM-score 0.97, RMSD 1.49 Å
- 6CPM chain D against the predicted model Q9Y4E8: TM-score 0.97, RMSD 1.49 Å
Elsewhere
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