UniProt Q9Y3Q4
Q9Y3Q4
Q9Y3Q4 (UniProt Q9Y3Q4): 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y3Q4
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
Structures
17 records of Q9Y3Q4 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MNG | Apo Structure of human HCN4 CNBD solved by NMR | solution nmr | A | — | — |
| 2MNG | Apo structure of human HCN4 cnbd solved by NMR | solution nmr | A | — | — |
| 3OTF | Structural basis for the cAMP-dependent gating in human HCN4 channel | x-ray diffraction | A | — | — |
| 3OTF | Structural basis for the camp-dependent gating in human HCN4 channel | x-ray diffraction | A | — | — |
| 3U11 | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | x-ray diffraction | A, B | — | — |
| 3U11 | Tetramerization dynamics of the C-terminus underlies isoform-specific camp-gating in hcn channels | x-ray diffraction | A, B | — | — |
| 4HBN | Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation | x-ray diffraction | A | — | — |
| 4HBN | Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation | x-ray diffraction | A | — | — |
| 4KL1 | HCN4 CNBD in complex with cGMP | x-ray diffraction | A, B, C, D | — | — |
| 4KL1 | HCN4 cnbd in complex with cgmp | x-ray diffraction | A, B, C, D | — | — |
| 4NVP | Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP | x-ray diffraction | A | — | — |
| 4NVP | Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-ch-camp | x-ray diffraction | A | — | — |
| 6GYN | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | electron microscopy | A, B, C, D | PC1, 3PE | — |
| 6GYN | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide- gated ion channel | electron microscopy | A, B, C, D | PC1, 3PE | — |
| 6GYO | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex… | electron microscopy | A, B, C, D | CMP, PC1, PIE, 3PE, UNX | — |
| 6GYO | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide- gated ion channel in complex… | electron microscopy | A, B, C, D | CMP, PC1, PIE, 3PE, UNX | — |
| Q9Y3Q4 | AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6GYO chain A against the predicted model Q9Y3Q4: TM-score 0.98, RMSD 1.11 Å
- 6GYO chain A against the predicted model Q9Y3Q4: TM-score 0.98, RMSD 1.11 Å
- 6GYO chain B against the predicted model Q9Y3Q4: TM-score 0.98, RMSD 1.11 Å
- 6GYO chain C against the predicted model Q9Y3Q4: TM-score 0.98, RMSD 1.11 Å
- 6GYO chain D against the predicted model Q9Y3Q4: TM-score 0.98, RMSD 1.11 Å
- 4NVP chain A against the predicted model Q9Y3Q4: TM-score 0.97, RMSD 1.32 Å
- 4NVP chain A against the predicted model Q9Y3Q4: TM-score 0.97, RMSD 1.32 Å
- 3OTF chain A against the predicted model Q9Y3Q4: TM-score 0.97, RMSD 1.01 Å
- 3OTF chain A against the predicted model Q9Y3Q4: TM-score 0.97, RMSD 1.01 Å
- 4HBN chain A against the predicted model Q9Y3Q4: TM-score 0.97, RMSD 1.10 Å
Elsewhere
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