MolNFT v2 · #151559 · protein
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
6GYO: “Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP”. Electron microscopy at 3.4, 5 ligands (PC1, 3PE, CMP). MolNFT v2 #151559 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GYO
- Type
- protein
- Length
- 2,004 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.4
- Source
- Homo sapiens
- UniProt
- Q9Y3Q4
- Ligands
- PC1, 3PE, CMP, PIE, UNX
Structure
electron microscopy · resolution 3.4 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 501 | — | Q9Y3Q4 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 28 copies · chains A, B, D, C
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 8 copies · chains A, B, C, D
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 4 copies · chains A, B, C, D
- PIE · 1,2-diacyl-sn-glycero-3-phosphoinositol · ligand · 4 copies · chains A, B, C, D
- UNX · Unknown atom or ion · ion · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6GYO · Structure of human HCN4 hyperpolarization-activated cyclic nucleotide- gated ion channel… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9Y3Q4 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3Q4
- Elsewhere: RCSB PDB 6GYO · PDBe 6GYO · UniProt Q9Y3Q4
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