MolNFT v1 · #80577 · protein
Tetramerization dynamics of the C-terminus underlies isoform-specific camp-gating in hcn channels
3U11 · POTASSIUM/SODIUM hyperpolarization-activated cyclic…: “Tetramerization dynamics of the C-terminus underlies isoform-specific camp-gating in hcn channels”. X-ray diffraction, 1 ligand (CMP), 4 pockets (best druggability 0.73). MolNFT…
- PDB
- 3U11
- Type
- protein
- Length
- 400 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4
- UniProt
- Q9Y3Q4
- Ligands
- CMP
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4 | protein | 198 | 52% helix, 22% strand | Q9Y3Q4 |
| B | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 4 | protein | 202 | 49% helix, 20% strand | Q9Y3Q4 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A, B
- GOL · Glycerol · additive · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.73 | 0.94 | 23 | CMP |
| 2 | 119 | 0.71 | 0.92 | 23 | CMP, GOL |
| 3 | 496 | 0.65 | 0.77 | 53 | GOL |
| 4 | 221 | 0.47 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 367 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 3U11 · Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y3Q4 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3Q4
- Elsewhere: RCSB PDB 3U11 · PDBe 3U11 · UniProt Q9Y3Q4
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