UniProt Q9Y231
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (Q9Y231)
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (UniProt Q9Y231), EC 2.4.1.152: 8 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 12 pockets. Binding sites, druggability and…
- UniProt
- Q9Y231
- Protein
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
- EC
- 2.4.1.152
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 12 · 4 records with a druggable one
Structures
9 records of Q9Y231 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8D0O | Human alpha1,3-fucosyltransferase FUT9, heavy atom derivative | x-ray diffraction | A | NAG, IOD, CS | 2 (best 0.51) |
| 8D0P | Human FUT9, unliganded | x-ray diffraction | A | NAG, SO4 | 1 (best 0.52) |
| 8D0Q | Human FUT9 bound to GDP-CF3-Fucose and H-Type 2 | x-ray diffraction | A | NAG, GAL, FUC, NDG, 6CK, GDP | 1 (best 0.47) |
| 8D0R | Human FUT9 bound to GDP and H-Type 2 | x-ray diffraction | A | NAG, GAL, FUC, GDP, SO4 | 2 (best 0.49) |
| 8D0S | Human FUT9 bound to GDP and LNnT | x-ray diffraction | A | NAG, GAL, GDP, SO4 | 2 (best 0.48) |
| 8D0U | Human FUT9 bound to GDP | x-ray diffraction | A | NAG, GDP, SO4 | 2 (best 0.51) |
| 8D0W | Human FUT9 bound to H-Type 2 | x-ray diffraction | A | NAG, GAL, FUC, SO4 | 1 (best 0.45) |
| 8D0X | Human FUT9 bound to LNnT | x-ray diffraction | A | NAG, GAL, SO4 | 1 (best 0.52) |
| Q9Y231 | AlphaFold monomer V2.0 prediction for 4-galactosyl-N- acetylglucosaminide… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- SO4 · Sulfate ion · in 7 records
- GAL · beta-D-galactopyranose · in 5 records
- GDP · Guanosine-5'-diphosphate · in 4 records
- FUC · alpha-L-fucopyranose · in 3 records
- 6CK · [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(trifluoromethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name) · in 1 record
- CS · Cesium ion · in 1 record
- IOD · Iodide ion · in 1 record
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 8D0Q chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.83 Å
- 8D0W chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.83 Å
- 8D0R chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.84 Å
- 8D0O chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.84 Å
- 8D0S chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.85 Å
- 8D0X chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.85 Å
- 8D0U chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.86 Å
- 8D0P chain A against the predicted model Q9Y231: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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