UniProt Q9WYT0
Flavin-dependent thymidylate synthase (Q9WYT0)
Flavin-dependent thymidylate synthase (UniProt Q9WYT0), EC 2.1.1.148: 69 experimental structures on GenesisL1, 9 ligands bound, 33 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9WYT0
- Protein
- Flavin-dependent thymidylate synthase
- EC
- 2.1.1.148
- Experimental structures
- 69
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 33 · 7 records with a druggable one
Structures
69 records of Q9WYT0 in the MolNFT archive: 69 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KQ4 | Crystal structure of a THY1-complementing protein (TM0449) from thermotoga maritima at 2.25 a… | x-ray diffraction | A, B, C, D | — | — |
| 1KQ4 | Crystal structure of a THY1-complementing protein (TM0449) from thermotoga maritima at 2.25 a… | x-ray diffraction | A, B, C, D | — | — |
| 1O24 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O24 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O25 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O25 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O26 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O26 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O27 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O27 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O28 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O28 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O29 | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O29 | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O2A | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O2A | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O2B | Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 1O2B | Crystal structure of thymidylate synthase complementing protein (TM0449) from thermotoga maritima… | x-ray diffraction | A, B, C, D | — | — |
| 3G4A | Crystal structure of flavine dependant thymidylate synthase S88A mutant from Thermotoga maritima at… | x-ray diffraction | A, B, C, D | — | — |
| 3G4A | Crystal structure of flavine dependant thymidylate synthase S88A mutant from thermotoga maritima at… | x-ray diffraction | A, B, C, D | — | — |
| 3G4C | Flavine dependant thymidylate syntahse S88C mutant | x-ray diffraction | A, B, C, D | — | — |
| 3G4C | Flavine dependant thymidylate syntahse S88C mutant | x-ray diffraction | A, B, C, D | — | — |
| 3N0B | TM0449 mutant crystals grown in loops/micromounts | x-ray diffraction | A, B, C, D | — | — |
| 3N0B | TM0449 mutant crystals grown in LOOPS/MICROMOUNTS | x-ray diffraction | A, B, C, D | — | — |
| 3N0C | TM0449 mutant crystal grown by hanging drop method | x-ray diffraction | A, B, C, D | — | — |
| 3N0C | TM0449 mutant crystal grown by hanging drop method | x-ray diffraction | A, B, C, D | — | — |
| 4GT9 | T. Maritima FDTS with FAD, dUMP and Folate. | x-ray diffraction | A | — | — |
| 4GT9 | T. maritima fdts with FAD, dump and folate. | x-ray diffraction | A | — | — |
| 4GTA | T. Maritima FDTS with FAD, dUMP, and Folinic Acid | x-ray diffraction | A | — | — |
| 4GTA | T. maritima fdts with FAD, dump, and folinic acid | x-ray diffraction | A | — | — |
| 4GTB | T. Maritima FDTS with FAD, dUMP, and Raltitrexed. | x-ray diffraction | A | — | — |
| 4GTB | T. maritima fdts with FAD, dump, and raltitrexed. | x-ray diffraction | A | — | — |
| 4GTC | T. Maritima FDTS (E144R mutant) plus FAD | x-ray diffraction | A, B, C, D | — | — |
| 4GTC | T. maritima fdts (E144R mutant) plus FAD | x-ray diffraction | A, B, C, D | — | — |
| 4GTD | T. Maritima FDTS (E144R mutant) with FAD and dUMP | x-ray diffraction | A, B, C, D | — | — |
| 4GTD | T. maritima fdts (E144R mutant) with FAD and dump | x-ray diffraction | A, B, C, D | — | — |
| 4GTE | T. Maritima FDTS (E144R mutant) with FAD and Folate | x-ray diffraction | A, B, C, D | — | — |
| 4GTE | T. maritima fdts (E144R mutant) with FAD and folate | x-ray diffraction | A, B, C, D | — | — |
| 4GTF | T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate | x-ray diffraction | A | — | — |
| 4GTF | T. maritima fdts (H53A mutant) with FAD, dump and folate | x-ray diffraction | A | — | — |
| 4GTL | T. Maritima FDTS (R174K mutant) with FAD | x-ray diffraction | A, B, C, D | — | — |
| 4GTL | T. maritima fdts (R174K mutant) with FAD | x-ray diffraction | A, B, C, D | — | — |
| 4KAR | Crystal structure of FDTS (TM0449) mutant (H53D) with FAD | x-ray diffraction | A, B, C, D | — | — |
| 4KAR | Crystal structure of fdts (TM0449) mutant (H53D) with FAD | x-ray diffraction | A, B, C, D | — | — |
| 4KAS | Crystal structure of FDTS from T. maritima mutant (H53D) with FAD and dUMP | x-ray diffraction | A, B, C, D | — | — |
| 4KAS | Crystal structure of fdts from T. maritima mutant (H53D) with FAD and dump | x-ray diffraction | A, B, C, D | — | — |
| 4KAT | Crystal structure of FDTS from T. maritima mutant (R174K) with FAD and dUMP | x-ray diffraction | A, B, C, D | — | — |
| 4KAT | Crystal structure of fdts from T. maritima mutant (R174K) with FAD and dump | x-ray diffraction | A, B, C, D | — | — |
| 5CHP | T. maritima ThyX in complex with TyC5-03 | x-ray diffraction | A | FAD, 51Q | — |
| 5CHP | T. maritima thyx in complex with TYC5-03 | x-ray diffraction | A | — | — |
| 5IOQ | Flavin-dependent thymidylate synthase in complex with FAD and deoxyuridine | x-ray diffraction | A, B, C, D | FAD, DUR | — |
| 5IOQ | Flavin-dependent thymidylate synthase in complex with FAD and deoxyuridine | x-ray diffraction | A, B, C, D | — | — |
| 5IOR | Flavin-dependent thymidylate synthase in complex with FAD and 2'-deoxyuridine-5'-monosulfate | x-ray diffraction | A | FAD, DUS | — |
| 5IOR | Flavin-dependent thymidylate synthase in complex with FAD and 2'- deoxyuridine-5'-monosulfate | x-ray diffraction | A | — | — |
| 5IOS | Flavin-dependent thymidylate synthase R90A variant in complex with FAD and deoxyuridine… | x-ray diffraction | A, B, C, D | FAD, UMP | — |
| 5IOS | Flavin-dependent thymidylate synthase R90A variant in complex with FAD and deoxyuridine… | x-ray diffraction | A, B, C, D | — | — |
| 5IOT | Flavin-dependent thymidylate synthase R174A variant in complex with FAD and dUMP | x-ray diffraction | A, B, C, D | FAD, UMP | 5 (best 0.86) |
| 5IOT | Flavin-dependent thymidylate synthase R174A variant in complex with FAD and dump | x-ray diffraction | A, B, C, D | FAD, UMP | 5 (best 0.86) |
| 5JFE | Flavin-dependent thymidylate synthase with H2-dUMP | x-ray diffraction | A | FAD, UMC | — |
| 5JFE | Flavin-dependent thymidylate synthase with H2-dump | x-ray diffraction | A | — | — |
9 records more on the page itself.
Ligands
- FAD · Flavin-adenine dinucleotide · in 8 records
- FDA · Dihydroflavine-adenine dinucleotide · in 7 records
- HUF · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate · in 4 records
- UMP · 2'-deoxyuridine 5'-monophosphate · in 4 records
- PO4 · Phosphate ion · in 2 records
- 51Q · (2S)-2-[(3-hydroxy-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid · in 1 record
- DUR · 2'-deoxyuridine · in 1 record
- DUS · 2'-deoxy-5'-O-sulfouridine · in 1 record
- UMC · 2'-deoxy-5'-uridylic acid · in 1 record
Elsewhere
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