GL1X · GenesisL1 explorer

Ligand · MEF

MEF · N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid

MEF, N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid (C20 H23 N7 O6, 457.4 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding…

Component
MEF
Formula
C20 H23 N7 O6
Class
ligand
Structures
8
PDB entries
4

Binding sites

MEF in 8 structures; the first of them:

  • 3BGX · E. coli Thymidylate Synthase C146S mutant complexed with dTMP and MTF · MEF A266 · binds LYS48, HIS51, SER54, GLU58, ILE79, TRP80, TRP83, LEU143 and 8 more
  • 4GT9 · T. Maritima FDTS with FAD, dUMP and Folate. · MEF A303 · binds ASN85, TYR91
  • 4GTE · T. Maritima FDTS (E144R mutant) with FAD and Folate · MEF B302 · binds GLN75, ARG78, LEU173, ARG174, HIS178, ALA179, SER88, ARG90 and 1 more
  • 4GTF · T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate · MEF A303 · binds ASN85, TYR91
  • 3BGX · E. COLI thymidylate synthase C146S mutant complexed with dtmp and mtf · MEF A266 · binds LYS48, HIS51, SER54, GLU58, ILE79, TRP80, TRP83, LEU143 and 8 more
  • 4GT9 · T. maritima fdts with FAD, dump and folate. · MEF A303 · binds ASN85, TYR91
  • 4GTE · T. maritima fdts (E144R mutant) with FAD and folate · MEF B302 · binds GLN75, ARG78, LEU173, ARG174, HIS178, ALA179, SER88, ARG90 and 1 more
  • 4GTF · T. maritima fdts (H53A mutant) with FAD, dump and folate · MEF A303 · binds ASN85, TYR91

Residues it binds most

ARG 4, LEU 6, TYR 8, ALA 6, HIS 6, ILE 4, ASN 4, GLN 4, GLU 4, GLY 4 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide
  • UMP · 2'-deoxyuridine 5'-monophosphate
  • CL · Chloride ion
  • TMP · Thymidine-5'-phosphate
  • SO4 · Sulfate ion
  • PEG · Di(hydroxyethyl)ether

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.