UniProt Q9UQD0
Sodium channel protein type 8 subunit alpha (Q9UQD0)
Sodium channel protein type 8 subunit alpha (UniProt Q9UQD0): 3 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UQD0
- Protein
- Sodium channel protein type 8 subunit alpha
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 79 · 4 records with a druggable one
Structures
4 records of Q9UQD0 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8FHD | Cryo-EM structure of human voltage-gated sodium channel Nav1.6 | electron microscopy | A | NAG, BMA, MAN, Y01, CLR, LPE | 20 (best 0.82) |
| 8GZ1 | Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | electron microscopy | B | NAG, BMA, NA | 20 (best 0.85) |
| 8GZ2 | Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | electron microscopy | B | NAG, BMA, WMK | 19 (best 0.86) |
| Q9UQD0 | AlphaFold monomer V2.0 prediction for sodium channel protein type 8 subunit alpha (Q9UQD0) | predicted | A | — | 20 (best 0.86) |
Ligands
- BMA · beta-D-mannopyranose · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 1 record
- CLR · Cholesterol · in 1 record
- LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- NA · Sodium ion · in 1 record
- P3X · (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate · in 1 record
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 1 record
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 1 record
- WMK · (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8GZ1 chain B against the predicted model Q9UQD0: TM-score 0.98, RMSD 1.59 Å
- 8GZ2 chain B against the predicted model Q9UQD0: TM-score 0.98, RMSD 1.63 Å
- 8FHD chain A against the predicted model Q9UQD0: TM-score 0.98, RMSD 1.84 Å
Elsewhere
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