UniProt Q9UQ84
Exonuclease 1 (Q9UQ84)
Exonuclease 1 (UniProt Q9UQ84), EC 3.1.-.-: 38 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UQ84
- Protein
- Exonuclease 1
- EC
- 3.1.-.-
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 82 · 16 records with a druggable one
Structures
39 records of Q9UQ84 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QE9 | Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I) | x-ray diffraction | Y, Z | — | — |
| 3QE9 | Crystal structure of human exonuclease 1 EXO1 (D173A) in complex with DNA (complex I) | x-ray diffraction | Y, Z | — | — |
| 3QEA | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II) | x-ray diffraction | Z | — | — |
| 3QEA | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with DNA (complex II) | x-ray diffraction | Z | — | — |
| 3QEB | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III) | x-ray diffraction | Z | — | — |
| 3QEB | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with DNA and MN2+ (complex III) | x-ray diffraction | Z | — | — |
| 5UZV | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rI) | x-ray diffraction | Z | NA | 5 (best 0.81) |
| 5UZV | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' recessed-end DNA (ri) | x-ray diffraction | Z | NA | — |
| 5V04 | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rII) | x-ray diffraction | Z | NA | 6 (best 0.74) |
| 5V04 | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' recessed-end DNA (rii) | x-ray diffraction | Z | NA | — |
| 5V05 | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rIII) | x-ray diffraction | Z | MN, NA | 6 (best 0.77) |
| 5V05 | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' recessed-end DNA (riii) | x-ray diffraction | Z | MN, NA | — |
| 5V06 | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rIV) | x-ray diffraction | Z | MN, NA | 4 (best 0.75) |
| 5V06 | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' recessed-end DNA (riv) | x-ray diffraction | Z | MN, NA | — |
| 5V07 | Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with 5' recessed-end DNA (rV) | x-ray diffraction | Z | MN, NA | 6 (best 0.75) |
| 5V07 | Crystal structure of human exonuclease 1 EXO1 (D173A) in complex with 5' recessed-end DNA (rv) | x-ray diffraction | Z | MN, NA | — |
| 5V08 | Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with 5' recessed-end DNA (rVI) | x-ray diffraction | Z | MG, NA | 6 (best 0.76) |
| 5V08 | Crystal structure of human exonuclease 1 EXO1 (D173A) in complex with 5' recessed-end DNA (rvi) | x-ray diffraction | Z | MG, NA | — |
| 5V09 | Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVII) | x-ray diffraction | Z | MN, NA | 6 (best 0.71) |
| 5V09 | Crystal structure of human exonuclease 1 EXO1 (D225A) in complex with 5' recessed-end DNA (rvii) | x-ray diffraction | Z | MN, NA | — |
| 5V0A | Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVIII) | x-ray diffraction | Z | MN, NA, D5M | 3 (best 0.79) |
| 5V0A | Crystal structure of human exonuclease 1 EXO1 (D225A) in complex with 5' recessed-end DNA (rviii) | x-ray diffraction | Z | MN, NA | — |
| 5V0B | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rIX) | x-ray diffraction | Z | MN, NA | 5 (best 0.80) |
| 5V0B | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' recessed-end DNA (rix) | x-ray diffraction | Z | MN, NA | — |
| 5V0C | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f2I) | x-ray diffraction | Z | NA | — |
| 5V0C | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' flap DNA (F2I) | x-ray diffraction | Z | NA | — |
| 5V0D | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f2II) | x-ray diffraction | Z | MG, NA | — |
| 5V0D | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' flap DNA (F2II) | x-ray diffraction | Z | MG, NA | — |
| 5V0E | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f5I) | x-ray diffraction | Z | NA | — |
| 5V0E | Crystal structure of human exonuclease 1 EXO1 (wt) in complex with 5' flap DNA (F5I) | x-ray diffraction | Z | NA | — |
| 7MXQ | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-1) | x-ray diffraction | Z | MN, NA | 5 (best 0.78) |
| 7MXR | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-2) | x-ray diffraction | Z | MN, NA | — |
| 7MXS | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cr) | x-ray diffraction | Z | MN, NA | 5 (best 0.77) |
| 7MXT | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cmr) | x-ray diffraction | Z | MN, NA | 5 (best 0.77) |
| 7MXU | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (cf2) | x-ray diffraction | Z | MN, NA | 5 (best 0.77) |
| 7MXV | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (ur) | x-ray diffraction | Z | MN, NA | 4 (best 0.79) |
| 7MXW | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (uf1) | x-ray diffraction | Z | MG, CA | 5 (best 0.77) |
| 7MXX | Crystal structure of human exonuclease 1 Exo1 (R92A) in complex with 5' flap DNA (uf4) | x-ray diffraction | Z | MN, CA | 6 (best 0.80) |
| Q9UQ84 | AlphaFold monomer V2.0 prediction for exonuclease 1 (Q9UQ84) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5V08 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.35 Å
- 5V08 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.35 Å
- 5V07 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.36 Å
- 5V07 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.36 Å
- 5V0A chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.38 Å
- 5V0A chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.38 Å
- 5V09 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.44 Å
- 5V09 chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.44 Å
- 7MXR chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.47 Å
- 7MXV chain Z against the predicted model Q9UQ84: TM-score 1.00, RMSD 0.48 Å
Elsewhere
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