UniProt Q9UKV8
Protein argonaute-2 (Q9UKV8)
Protein argonaute-2 (UniProt Q9UKV8), EC 3.1.26.-: 83 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 615 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UKV8
- Protein
- Protein argonaute-2
- EC
- 3.1.26.-
- Experimental structures
- 83
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 615 · 67 records with a druggable one
Structures
84 records of Q9UKV8 in the MolNFT archive: 83 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LUC | Crystal structure of MID domain from hAGO2 | x-ray diffraction | A, B, C | PO4 | 4 (best 0.41) |
| 3LUC | Crystal structure of mid domain from HAGO2 | x-ray diffraction | A, B, C | PO4 | 4 (best 0.41) |
| 3LUD | Crystal structure of MID domain from hAGO2 in complex with AMP | x-ray diffraction | A, B, C | AMP, PO4 | 3 (best 0.39) |
| 3LUD | Crystal structure of mid domain from HAGO2 in complex with AMP | x-ray diffraction | A, B, C | AMP, PO4 | 3 (best 0.39) |
| 3LUG | Crystal structure of MID domain from hAGO2 in complex with CMP | x-ray diffraction | A, B, C | PO4, C5P | 4 (best 0.41) |
| 3LUG | Crystal structure of mid domain from HAGO2 in complex with cmp | x-ray diffraction | A, B, C | PO4, C5P | 4 (best 0.41) |
| 3LUH | Crystal structure of MID domain from hAGO2 in complex with GMP | x-ray diffraction | A, B, C | 5GP, PO4 | 3 (best 0.42) |
| 3LUH | Crystal structure of mid domain from HAGO2 in complex with gmp | x-ray diffraction | A, B, C | 5GP, PO4 | 3 (best 0.42) |
| 3LUJ | Crystal structure of MID domain from hAGO2 in complex with UMP | x-ray diffraction | A, B, C | U5P | 5 (best 0.37) |
| 3LUJ | Crystal structure of mid domain from HAGO2 in complex with ump | x-ray diffraction | A, B, C | U5P | 5 (best 0.37) |
| 3LUK | Crystal structure of MID domain from hAGO2 | x-ray diffraction | A, B, C | PO4 | 4 (best 0.38) |
| 3LUK | Crystal structure of mid domain from HAGO2 | x-ray diffraction | A, B, C | PO4 | 4 (best 0.38) |
| 3QX8 | Crystal structure of MID domain from hAGO2 in complex with m7GpppG | x-ray diffraction | A, B, C | GTG | 4 (best 0.35) |
| 3QX8 | Crystal structure of mid domain from HAGO2 in complex with M7GPPPG | x-ray diffraction | A, B, C | GTG | 4 (best 0.35) |
| 3QX9 | Crystal structure of MID domain from hAGO2 in complex with ATP | x-ray diffraction | A, B, C | ATP | 3 (best 0.42) |
| 3QX9 | Crystal structure of mid domain from HAGO2 in complex with ATP | x-ray diffraction | A, B, C | ATP | 3 (best 0.42) |
| 4F3T | Human Argonaute-2 - miR-20a complex | x-ray diffraction | A | IPH | 9 (best 0.81) |
| 4F3T | Human argonaute-2 - mir-20A complex | x-ray diffraction | A | IPH | 9 (best 0.81) |
| 4OLA | Crystal Structure of Human Argonaute2 | x-ray diffraction | A | IPH | 4 (best 0.80) |
| 4OLA | Crystal structure of human ARGONAUTE2 | x-ray diffraction | A | IPH | 4 (best 0.80) |
| 4OLB | Crystal Structure of Human Argonaute2 Bound to Tryptophan | x-ray diffraction | A | TRP | 6 (best 0.73) |
| 4OLB | Crystal structure of human ARGONAUTE2 bound to tryptophan | x-ray diffraction | A | TRP | 6 (best 0.73) |
| 4W5N | The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA | x-ray diffraction | A | IPH, MG | 10 (best 0.79) |
| 4W5N | The crystal structure of human ARGONAUTE2 bound to a defined guide RNA | x-ray diffraction | A | IPH, MG | 10 (best 0.79) |
| 4W5O | The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing… | x-ray diffraction | A | MG, IPH, PO4 | 8 (best 0.87) |
| 4W5O | The crystal structure of human ARGONAUTE2 bound to a guide and target RNA containing seed pairing… | x-ray diffraction | A | MG, IPH, PO4 | 8 (best 0.87) |
| 4W5Q | The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing… | x-ray diffraction | A | MG, IPH | 9 (best 0.88) |
| 4W5Q | The crystal structure of human ARGONAUTE2 bound to a guide and target RNA containing seed pairing… | x-ray diffraction | A | MG, IPH | 9 (best 0.88) |
| 4W5R | The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing… | x-ray diffraction | A | IPH, MG | 7 (best 0.79) |
| 4W5R | The crystal structure of human ARGONAUTE2 bound to a guide and target RNA containing seed pairing… | x-ray diffraction | A | IPH, MG | 7 (best 0.79) |
| 4W5T | The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing… | x-ray diffraction | A | MG, IPH | 8 (best 0.81) |
| 4W5T | The crystal structure of human ARGONAUTE2 bound to a guide and target RNA containing seed pairing… | x-ray diffraction | A | MG, IPH | 8 (best 0.81) |
| 4Z4C | Human Argonaute2 Bound to t1-C Target RNA | x-ray diffraction | A | MG, IPH, PO4 | 6 (best 0.87) |
| 4Z4C | Human ARGONAUTE2 bound to T1-C target RNA | x-ray diffraction | A | MG, IPH, PO4 | 6 (best 0.87) |
| 4Z4D | Human Argonaute2 Bound to t1-G Target RNA | x-ray diffraction | A | MG, IPH | 7 (best 0.88) |
| 4Z4D | Human ARGONAUTE2 bound to T1-G target RNA | x-ray diffraction | A | MG, IPH | 7 (best 0.88) |
| 4Z4E | Human Argonaute2 Bound to t1-U Target RNA | x-ray diffraction | A | MG, IPH, PO4 | 9 (best 0.88) |
| 4Z4E | Human ARGONAUTE2 bound to T1-U target RNA | x-ray diffraction | A | MG, IPH, PO4 | 9 (best 0.88) |
| 4Z4F | Human Argonaute2 Bound to t1-DAP Target RNA | x-ray diffraction | A | MG, IPH | 8 (best 0.88) |
| 4Z4F | Human ARGONAUTE2 bound to T1-dap target RNA | x-ray diffraction | A | MG, IPH | 8 (best 0.88) |
| 4Z4G | Human Argonaute2 Bound to t1-Inosine Target RNA | x-ray diffraction | A | MG, IPH | 5 (best 0.87) |
| 4Z4G | Human ARGONAUTE2 bound to T1-inosine target RNA | x-ray diffraction | A | IMP, MG, IPH | 5 (best 0.87) |
| 4Z4H | Human Argonaute2 A481T Mutant Bound to t1-A Target RNA | x-ray diffraction | A | MG, IPH | 9 (best 0.88) |
| 4Z4H | Human ARGONAUTE2 A481T mutant bound to T1-a target RNA | x-ray diffraction | A | MG, IPH | 9 (best 0.88) |
| 4Z4I | Human Argonaute2 A481T Mutant Bound to t1-G Target RNA | x-ray diffraction | A | MG, IPH | 7 (best 0.88) |
| 4Z4I | Human ARGONAUTE2 A481T mutant bound to T1-G target RNA | x-ray diffraction | A | MG, IPH | 7 (best 0.88) |
| 5JS1 | Human Argonaute2 Bound to an siRNA | x-ray diffraction | A | IPH, MG | 6 (best 0.82) |
| 5JS1 | Human ARGONAUTE2 bound to an siRNA | x-ray diffraction | A | IPH, MG | 6 (best 0.82) |
| 5JS2 | Human Argonaute-2 Bound to a Modified siRNA | x-ray diffraction | A | IPH, PO4, MG | 6 (best 0.78) |
| 5JS2 | Human argonaute-2 bound to a modified siRNA | x-ray diffraction | A | IPH, PO4, MG | 6 (best 0.78) |
| 5KI6 | Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1 | x-ray diffraction | A | IPH | 5 (best 0.80) |
| 5KI6 | Human argonaute-2 bound to a guide RNA with a nucleobase modification at position 1 | x-ray diffraction | A | IPH | 5 (best 0.80) |
| 5T7B | Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrTTR guide RNA complex | x-ray diffraction | A | IPH | 10 (best 0.83) |
| 5T7B | Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrttr guide RNA complex | x-ray diffraction | A | IPH | 10 (best 0.83) |
| 5WEA | Human Argonaute2 Helix-7 Mutant | x-ray diffraction | A | IPH | 5 (best 0.73) |
| 5WEA | Human ARGONAUTE2 helix-7 mutant | x-ray diffraction | A | IPH | 5 (best 0.73) |
| 6CBD | Crystal Structure of Human Argonaute2 Bound to Three Tryptophans | x-ray diffraction | A | TRP, MG | 8 (best 0.88) |
| 6CBD | Crystal structure of human ARGONAUTE2 bound to three tryptophans | x-ray diffraction | A | TRP, MG | 8 (best 0.88) |
| 6MDZ | Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2) | x-ray diffraction | A, B | IPH | 20 (best 0.85) |
| 6MDZ | Human ARGONAUTE2-mir-122 bound to a target RNA with two central mismatches (BU2) | x-ray diffraction | A, B | IPH | 20 (best 0.85) |
24 records more on the page itself.
Ligands
- IPH · Phenol · in 44 records
- MG · Magnesium ion · in 33 records
- PO4 · Phosphate ion · in 22 records
- TRP · Tryptophan · in 4 records
- 5GP · Guanosine-5'-monophosphate · in 2 records
- 8BR · 8-bromo-adenosine-5'-monophosphate · in 2 records
- AMP · Adenosine monophosphate · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- BA · Barium ion · in 2 records
- C5P · Cytidine-5'-monophosphate · in 2 records
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · in 2 records
- K2R · 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid · in 2 records
- U5P · Uridine-5'-monophosphate · in 2 records
- A1ANT · [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate · in 1 record
- IMP · Inosinic acid · in 1 record
- U · Uridine-5'-monophosphate · in 1 record
- UTP · Uridine 5'-triphosphate · in 1 record
Experiment against prediction
- 4W5T chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4W5T chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4D chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4D chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4C chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4C chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4E chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4E chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4I chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
- 4Z4I chain A against the predicted model Q9UKV8: TM-score 0.98, RMSD 1.53 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.