UniProt Q9UJM8
Hydroxyacid oxidase 1 (Q9UJM8)
Hydroxyacid oxidase 1 (UniProt Q9UJM8), EC 1.1.3.15: 37 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UJM8
- Protein
- Hydroxyacid oxidase 1
- EC
- 1.1.3.15
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 32 · 10 records with a druggable one
Structures
38 records of Q9UJM8 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NZL | Crystal structure of human hydroxyacid oxidase 1 | x-ray diffraction | A | — | — |
| 2NZL | Crystal structure of human hydroxyacid oxidase 1 | x-ray diffraction | A | — | — |
| 2RDT | Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST | x-ray diffraction | A | — | — |
| 2RDT | Crystal structure of human glycolate oxidase (go) in complex with cdst | x-ray diffraction | A | — | — |
| 2RDU | Crystal Structure of Human Glycolate Oxidase in Complex with Glyoxylate | x-ray diffraction | A | — | — |
| 2RDU | Crystal structure of human glycolate oxidase in complex with glyoxylate | x-ray diffraction | A | — | — |
| 2RDW | Crystal Structure of Human Glycolate Oxidase in Complex with Sulfate | x-ray diffraction | A | — | — |
| 2RDW | Crystal structure of human glycolate oxidase in complex with sulfate | x-ray diffraction | A | — | — |
| 2W0U | Crystal structure of human glycolate oxidase in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 2W0U | Crystal structure of human glycolate oxidase in complex with the inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 5QIB | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal… | x-ray diffraction | A | FNR, GX7 | 3 (best 0.81) |
| 5QIB | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FNR, GX7 | — |
| 5QIC | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal… | x-ray diffraction | A | FMN, GX4 | 4 (best 0.82) |
| 5QIC | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GX4 | — |
| 5QID | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal… | x-ray diffraction | A | FMN, GWY | 2 (best 0.82) |
| 5QID | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GWY | — |
| 5QIE | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal… | x-ray diffraction | A | FMN, GWV | 4 (best 0.80) |
| 5QIE | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GWV | — |
| 5QIF | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GWS | — |
| 5QIG | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GWP | — |
| 5QIH | Pandda analysis group deposition of models with modelled events (E.G. bound ligands) -- crystal… | x-ray diffraction | A | FMN, GWG | — |
| 6GMB | Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate | x-ray diffraction | A | FMN, GOA | — |
| 6GMC | 1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and… | x-ray diffraction | A | FMN, C7C | — |
| 6GMC | 1.2 a resolution structure of human hydroxyacid oxidase 1 bound with FMN and… | x-ray diffraction | A | FMN, C7C | — |
| 6W44 | Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 4 | x-ray diffraction | A | FMN, SLJ | 3 (best 0.76) |
| 6W44 | Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 4 | x-ray diffraction | A | FMN, SLJ | — |
| 6W45 | Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 | x-ray diffraction | A | SLG, FMN | 4 (best 0.77) |
| 6W45 | Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 | x-ray diffraction | A | SLG, FMN | — |
| 6W4C | Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 | x-ray diffraction | A | FMN, SL7 | 3 (best 0.80) |
| 6W4C | Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 | x-ray diffraction | A | FMN, SL7 | — |
| 7M2O | Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15 | x-ray diffraction | A | FMN, YOJ | 3 (best 0.78) |
| 7M2O | Crystal structure of human glycolate oxidase with inhibitor compound 15 | x-ray diffraction | A | FMN, YOJ | — |
| 7R4N | Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl- 1H-indazole-3-carboxamide | x-ray diffraction | A | 7RI, FMN | — |
| 7R4O | Structure of human hydroxyacid oxidase 1 bound with… | x-ray diffraction | A | I2W, FMN | 3 (best 0.80) |
| 7R4O | Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4… | x-ray diffraction | A | I2W, FMN | — |
| 7R4P | Structure of human hydroxyacid oxidase 1 bound with… | x-ray diffraction | A | FMN, I2Z | 3 (best 0.79) |
| 7R4P | Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl… | x-ray diffraction | A | FMN, I2Z | — |
| Q9UJM8 | AlphaFold monomer V2.0 prediction for hydroxyacid oxidase 1 (Q9UJM8) | predicted | A | — | — |
Ligands
- FMN · Flavin mononucleotide · in 25 records
- C7C · 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate · in 2 records
- FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · in 2 records
- GWV · ~{N},~{N}-dimethyl-4-[(propan-2-ylamino)methyl]aniline · in 2 records
- GWY · 5-chloranyl-~{N}-methyl-~{N}-[[(3~{S})-oxolan-3-yl]methyl]pyrimidin-4-amine · in 2 records
- GX4 · cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone · in 2 records
- GX7 · 5-(cyclohexylamino)pyrimidine-2,4(1H,3H)-dione · in 2 records
- I2W · 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl) piperazin-1-yl)ethan-1-one · in 2 records
- I2Z · 6-amino-1-benzyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione · in 2 records
- SL7 · 5-[[3-[3-(dimethylamino)-1,2,4-oxadiazol-5-yl]-2-oxidanyl-phenyl]methylamino]-2~{H}-indazole-3-carboxylic acid · in 2 records
- SLG · 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl) carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid · in 2 records
- SLJ · 5-[methyl-[(2-propoxypyridin-3-yl)methyl]amino]-2~{H}-indazole-3-carboxylic acid · in 2 records
- YOJ · 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl) methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid · in 2 records
- 7RI · 5-bromanyl-N-methyl-1H-indazole-3-carboxamide · in 1 record
- GOA · Glycolic acid · in 1 record
- GWG · 1-methylindazole-3-carboxamide · in 1 record
- GWP · 2-cyclopropyl-1~{H}-imidazole-4-carboxamide · in 1 record
- GWS · 2-cyclohexyl-~{N}-pyridin-3-yl-ethanamide · in 1 record
Experiment against prediction
- 5QID chain A against the predicted model Q9UJM8: TM-score 1.00, RMSD 0.48 Å
- 5QID chain A against the predicted model Q9UJM8: TM-score 1.00, RMSD 0.48 Å
- 2NZL chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 2NZL chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 5QIC chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 5QIC chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 5QIH chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 5QIB chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 5QIB chain A against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.49 Å
- 2W0U chain B against the predicted model Q9UJM8: TM-score 0.99, RMSD 0.48 Å
Elsewhere
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