UniProt Q9UHX1
Poly(U)-binding-splicing factor PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (UniProt Q9UHX1): 26 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UHX1
- Protein
- Poly(U)-binding-splicing factor PUF60
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 90 · 13 records with a druggable one
Structures
27 records of Q9UHX1 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KXF | Solution structure of the first two RRM domains of FBP-interacting repressor (FIR) | solution nmr | A | — | 3 (best 0.51) |
| 2KXF | Solution structure of the first two rrm domains of fbp-interacting repressor (fir) | solution nmr | A | — | 3 (best 0.51) |
| 2KXH | Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide | solution nmr | A | — | 3 (best 0.60) |
| 2KXH | Solution structure of the first two rrm domains of fir in the complex with fbp nbox peptide | solution nmr | A | — | — |
| 3DXB | Structure of the UHM domain of Puf60 fused to thioredoxin | x-ray diffraction | A, B, C, D, E, F, G, H | CL | 20 (best 0.77) |
| 3DXB | Structure of the uhm domain of PUF60 fused to thioredoxin | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3UE2 | Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo… | x-ray diffraction | A | SO4 | — |
| 3UE2 | Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDA (PUF60) from homo… | x-ray diffraction | A | — | — |
| 3US5 | Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDa (PUF60) from… | x-ray diffraction | A | CL | 1 (best 0.42) |
| 3US5 | Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDA (PUF60) from… | x-ray diffraction | A | — | — |
| 3UWT | Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo… | x-ray diffraction | A | CL | 1 (best 0.34) |
| 3UWT | Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDA (PUF60) from homo… | x-ray diffraction | A | — | — |
| 5KVY | Crystal structure of the two tandem rrm domains of PUF60 bound to a portion of an adml pre-mRNA 3'… | x-ray diffraction | A, B | CL | 3 (best 0.72) |
| 5KVY | Crystal structure of the two tandem rrm domains of PUF60 bound to a portion of an adml pre-mRNA 3'… | x-ray diffraction | A, B | CL | — |
| 5KW1 | Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3'… | x-ray diffraction | A, B | CL | 4 (best 0.71) |
| 5KW1 | Crystal structure of the two tandem rrm domains of PUF60 bound to a modified adml pre-mRNA 3'… | x-ray diffraction | A, B | CL | — |
| 5KW6 | Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified… | x-ray diffraction | A, B | — | 3 (best 0.72) |
| 5KW6 | Two tandem rrm domains of PUF60 bound to an adml pre-mRNA 3' splice site analogue with a modified… | x-ray diffraction | A, B | — | — |
| 5KWQ | Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 | x-ray diffraction | A, B | — | 3 (best 0.73) |
| 5KWQ | Two tandem rrm domains of fbp-interacting repressor (fir), also known as PUF60 | x-ray diffraction | A, B | — | — |
| 6LUR | Human PUF60 UHM domain (thioredoxin fusion) in complex with a small molecule binder | x-ray diffraction | A, B, C, D, E, F, G, H | EVU | 20 (best 0.81) |
| 6LUR | Human PUF60 uhm domain (thioredoxin fusion) in complex with a small molecule binder | x-ray diffraction | A, B, C, D, E, F, G, H | EVU | — |
| 6SLO | Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | x-ray diffraction | A, B, C, D | MG, LJT | 10 (best 0.77) |
| 6SLO | Crystal structure of PUF60 uhm domain in complex with 7,8 dimethoxyperphenazine | x-ray diffraction | A, B, C, D | MG, LJT | — |
| 7Q8A | Crystal structure of tandem domain RRM1-2 of FUBP-interacting repressor (FIR) bound to FUSE ssDNA… | x-ray diffraction | A, B | — | 8 (best 0.59) |
| 7Z3X | Crystal structure of FIR RRM1-2 Y115F mutant bound to FUSE ssDNA | x-ray diffraction | A, B | — | 5 (best 0.51) |
| Q9UHX1 | AlphaFold monomer V2.0 prediction for POLY(U)-binding-splicing factor PUF60 (Q9UHX1) | predicted | A | — | 3 (best 0.54) |
Ligands
Experiment against prediction
- 3DXB chain A against the predicted model P0AA27: TM-score 0.50, RMSD 1.02 Å
- 3DXB chain A against the predicted model P0AA27: TM-score 0.50, RMSD 1.02 Å
- 3DXB chain D against the predicted model P0AA27: TM-score 0.50, RMSD 1.09 Å
- 3DXB chain D against the predicted model P0AA27: TM-score 0.50, RMSD 1.09 Å
- 6LUR chain B against the predicted model P0AA25: TM-score 0.50, RMSD 0.36 Å
- 6LUR chain A against the predicted model P0AA25: TM-score 0.50, RMSD 0.38 Å
- 6LUR chain D against the predicted model P0AA25: TM-score 0.50, RMSD 0.93 Å
- 7Q8A chain A against the predicted model Q9UHX1: TM-score 0.97, RMSD 0.93 Å
- 7Z3X chain B against the predicted model Q9UHX1: TM-score 0.97, RMSD 0.93 Å
- 6LUR chain E against the predicted model P0AA25: TM-score 0.50, RMSD 0.42 Å
Elsewhere
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