MolNFT v1 · #125030 · protein

Two tandem rrm domains of fbp-interacting repressor (fir), also known as PUF60

5KWQ · POLY(U)-binding-splicing factor PUF60: “Two tandem rrm domains of fbp-interacting repressor (fir), also known as PUF60”. X-ray diffraction, 3 pockets (best druggability 0.73). MolNFT v1 #125030 on GenesisL1: 3D structure, binding…

PDB: 5KWQ
Type: protein
Length: 381 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: POLY(U)-binding-splicing factor PUF60
UniProt: Q9UHX1
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	POLY(U)-binding-splicing factor PUF60	protein	190	35% helix, 24% strand	Q9UHX1
B	POLY(U)-binding-splicing factor PUF60	protein	191	35% helix, 24% strand	Q9UHX1

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	870	0.73	0.77	85	empty
2	64	0.30	0.74	12	empty
3	62	0.29	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 728 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5KWQ · Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 · the same entry in another collection · chain A against A, TM-score 1.00
Q9UHX1 · AlphaFold monomer V2.0 prediction for POLY(U)-binding-splicing factor PUF60 (Q9UHX1) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UHX1
Elsewhere: RCSB PDB 5KWQ · PDBe 5KWQ · UniProt Q9UHX1

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