UniProt Q9UBL3
Set1/Ash2 histone methyltransferase complex subunit ASH2 (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (UniProt Q9UBL3): 48 experimental structures and 1 predicted model on GenesisL1, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UBL3
- Protein
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Experimental structures
- 48
- Predicted models
- 1
- Pockets
- 21 · 14 records with a druggable one
Structures
49 records of Q9UBL3 in the MolNFT archive: 48 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RSN | Crystal Structure of the N-terminal region of Human Ash2L | x-ray diffraction | A | — | — |
| 3RSN | Crystal structure of the N-terminal region of human ASH2L | x-ray diffraction | A | — | — |
| 3S32 | Crystal structure of Ash2L N-terminal domain | x-ray diffraction | A | — | — |
| 3S32 | Crystal structure of ASH2L N-terminal domain | x-ray diffraction | A | — | — |
| 3TOJ | Structure of the SPRY domain of human Ash2L | x-ray diffraction | A, B | — | — |
| 3TOJ | Structure of the spry domain of human ASH2L | x-ray diffraction | A, B | — | — |
| 4RIQ | Crystal structure of DPY-30 dimerization/docking domain in complex with Ash2L Sdc1-DPY-30… | x-ray diffraction | C, F, I, L, O, R, U, X | — | — |
| 4RIQ | Crystal structure of dpy-30 DIMERIZATION/DOCKING domain in complex with ASH2L SDC1-dpy-30… | x-ray diffraction | C, F, I, L, O, R, U, X | — | — |
| 4X8N | Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5 | x-ray diffraction | A | — | — |
| 4X8N | Crystal structure of ASH2L spry domain in complex with phosphorylated RBBP5 | x-ray diffraction | A | — | — |
| 4X8P | Crystal structure of Ash2L SPRY domain in complex with RbBP5 | x-ray diffraction | A | — | — |
| 4X8P | Crystal structure of ASH2L spry domain in complex with RBBP5 | x-ray diffraction | A | — | — |
| 5F6K | Crystal structure of the MLL3-Ash2L-RbBP5 complex | x-ray diffraction | A, B | — | — |
| 5F6K | Crystal structure of the MLL3-ASH2L-RBBP5 complex | x-ray diffraction | A, B | — | — |
| 5F6L | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | x-ray diffraction | B | — | — |
| 5F6L | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RBBP5 and ASH2L | x-ray diffraction | B | — | — |
| 6E2H | Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30 | x-ray diffraction | D | — | — |
| 6E2H | Crystal structure of human ASH2L (spry domain and sdi motif) in complex with full length dpy-30 | x-ray diffraction | D | — | — |
| 6KIU | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | electron microscopy | T | — | 2 (best 0.78) |
| 6KIU | Cryo-EM structure of human MLL1-ubncp complex (3.2 ångström) | electron microscopy | T | — | — |
| 6KIV | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | electron microscopy | T | — | 1 (best 0.78) |
| 6KIV | Cryo-EM structure of human MLL1-ubncp complex (4.0 ångström) | electron microscopy | T | — | — |
| 6KIW | Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | electron microscopy | T | — | 1 (best 0.66) |
| 6KIW | Cryo-EM structure of human MLL3-ubncp complex (4.0 ångström) | electron microscopy | T | — | — |
| 6KIX | Cryo-EM structure of human MLL1-NCP complex, binding mode1 | electron microscopy | T | — | — |
| 6KIX | Cryo-EM structure of human MLL1-ncp complex, binding MODE1 | electron microscopy | T | — | — |
| 6KIZ | Cryo-EM structure of human MLL1-NCP complex, binding mode2 | electron microscopy | T | — | — |
| 6KIZ | Cryo-EM structure of human MLL1-ncp complex, binding MODE2 | electron microscopy | T | — | — |
| 6PWV | Cryo-EM structure of MLL1 core complex bound to the nucleosome | electron microscopy | D | — | 1 (best 0.81) |
| 6PWV | Cryo-EM structure of MLL1 core complex bound to the nucleosome | electron microscopy | D | — | — |
| 6W5I | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | — |
| 6W5I | Cryo-EM structure of MLL1 in complex with RBBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | — |
| 6W5M | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | 1 (best 0.75) |
| 6W5M | Cryo-EM structure of MLL1 in complex with RBBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | — |
| 6W5N | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | 1 (best 0.75) |
| 6W5N | Cryo-EM structure of MLL1 in complex with RBBP5, WDR5, SET1, and ASH2L bound to the nucleosome… | electron microscopy | D | — | — |
| 7BRE | The crystal structure of MLL2 in complex with ASH2L and RBBP5 | x-ray diffraction | A, D | — | 3 (best 0.52) |
| 7BRE | The crystal structure of MLL2 in complex with ASH2L and RBBP5 | x-ray diffraction | A, D | — | — |
| 7MBM | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01 | electron microscopy | D | — | 2 (best 0.80) |
| 7MBM | Cryo-EM structure of MLL1-ncp (H3K4M) complex, MODE01 | electron microscopy | D | — | — |
| 7MBN | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02 | electron microscopy | D | — | 1 (best 0.74) |
| 7MBN | Cryo-EM structure of MLL1-ncp (H3K4M) complex, MODE02 | electron microscopy | D | — | — |
| 7UD5 | Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | electron microscopy | M | — | — |
| 7W67 | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide | x-ray diffraction | A | — | 1 (best 0.58) |
| 7W6A | Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex | x-ray diffraction | A | — | 1 (best 0.59) |
| 7W6I | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide | x-ray diffraction | A | — | 2 (best 0.52) |
| 7W6J | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide | x-ray diffraction | A | — | 1 (best 0.59) |
| 7W6L | The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | x-ray diffraction | A, B | — | 3 (best 0.71) |
| Q9UBL3 | AlphaFold monomer V2.0 prediction for SET1/ASH2 histone methyltransferase complex subunit ASH2… | predicted | A | — | — |
Experiment against prediction
- 4X8P chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.39 Å
- 4X8P chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.39 Å
- 7W6L chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.43 Å
- 5F6K chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.45 Å
- 5F6K chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.45 Å
- 7W6A chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.45 Å
- 4X8N chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.46 Å
- 4X8N chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.46 Å
- 7W67 chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.46 Å
- 7W6I chain A against the predicted model Q9UBL3: TM-score 0.99, RMSD 0.46 Å
Elsewhere
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