UniProt Q9UBH6
Solute carrier family 53 member 1 (Q9UBH6)
Solute carrier family 53 member 1 (UniProt Q9UBH6): 16 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 208 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UBH6
- Protein
- Solute carrier family 53 member 1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 208 · 15 records with a druggable one
Structures
17 records of Q9UBH6 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IJH | Structure of the SPX domain of the human phosphate transporter XPR1 in complex with a sulfate ion | x-ray diffraction | A, B | SO4 | — |
| 5IJH | Structure of the spx domain of the human phosphate transporter XPR1 in complex with a sulfate ion | x-ray diffraction | A, B | — | — |
| 8TYU | High-resolution crystal structure of the SPX domain of XPR1 at 1.4 angstroms | x-ray diffraction | B, A | — | 4 (best 0.62) |
| 8TYV | Crystal structure of the SPX domain of XPR1 in complex with IP8 | x-ray diffraction | B, A | I8P | 1 (best 0.60) |
| 8X5B | Cryo-EM structures of human XPR1 in closed states | electron microscopy | F, A | PO4, POV, CLR | 16 (best 0.82) |
| 8X5E | Cryo-EM structure of human XPR1 in open state | electron microscopy | A | PO4, 6OU | 5 (best 0.82) |
| 8X5F | human XPR1 in complex with InsP6 | electron microscopy | A, B | PO4, IHP, POV, CLR | 20 (best 0.81) |
| 8YET | Cryo EM structure of human phosphate channel XPR1 in complex with IP6 | electron microscopy | A, B | IHP | 20 (best 0.84) |
| 8YEX | Cryo EM structure of human phosphate channel XPR1 at apo state | electron microscopy | A, B | — | 14 (best 0.82) |
| 8YF4 | Cryo EM structure of human phosphate channel XPR1 at open and inward-facing state | electron microscopy | A, B | Y01 | 17 (best 0.83) |
| 8YFD | Cryo EM structure of human phosphate channel XPR1 at open state | electron microscopy | A, B | — | 14 (best 0.83) |
| 8YFU | Cryo EM structure of human phosphate channel XPR1 at intermediate state | electron microscopy | A, B | — | 19 (best 0.85) |
| 8YFW | Cryo EM structure of human phosphate channel XPR1 at intermediate state | electron microscopy | A, B | — | 17 (best 0.85) |
| 8YFX | Cryo EM structure of human phosphate channel XPR1 at inward-facing state | electron microscopy | A, B | — | 17 (best 0.83) |
| 9IWS | Cryo EM structure of human phosphate channel XPR1 in complex with IP7 | electron microscopy | A, B | I7P | 20 (best 0.81) |
| 9J4X | CryoEM structure of human XPR1 in apo state | electron microscopy | A, B | PC1 | 14 (best 0.80) |
| Q9UBH6 | AlphaFold monomer V2.0 prediction for xenotropic and polytropic retrovirus receptor 1 (Q9UBH6) | predicted | A | — | 10 (best 0.82) |
Ligands
- PO4 · Phosphate ion · in 3 records
- CLR · Cholesterol · in 2 records
- IHP · Inositol hexakisphosphate · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- I7P · (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 1 record
- I8P · (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] · in 1 record
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 1 record
- SO4 · Sulfate ion · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8TYV chain A against the predicted model Q9UBH6: TM-score 0.99, RMSD 0.56 Å
- 8TYV chain B against the predicted model Q9UBH6: TM-score 0.98, RMSD 0.72 Å
- 8YFD chain A against the predicted model Q9UBH6: TM-score 0.97, RMSD 1.45 Å
- 8TYU chain A against the predicted model Q9UBH6: TM-score 0.97, RMSD 1.03 Å
- 8YF4 chain A against the predicted model Q9UBH6: TM-score 0.97, RMSD 1.47 Å
- 8TYU chain B against the predicted model Q9UBH6: TM-score 0.97, RMSD 1.02 Å
- 8X5E chain A against the predicted model Q9UBH6: TM-score 0.95, RMSD 1.78 Å
- 8X5F chain A against the predicted model Q9UBH6: TM-score 0.94, RMSD 2.48 Å
- 8YEX chain A against the predicted model Q9UBH6: TM-score 0.94, RMSD 2.00 Å
- 9IWS chain A against the predicted model Q9UBH6: TM-score 0.94, RMSD 2.36 Å
Elsewhere
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