UniProt Q9UBB5
Methyl-CpG-binding domain protein 2 (Q9UBB5)
Methyl-CpG-binding domain protein 2 (UniProt Q9UBB5): 27 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UBB5
- Protein
- Methyl-CpG-binding domain protein 2
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 43 · 12 records with a druggable one
Structures
28 records of Q9UBB5 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2L2L | Solution structure of the coiled-coil complex between MBD2 and p66alpha | solution nmr | B | — | — |
| 2L2L | Solution structure of the coiled-coil complex between MBD2 and P66ALPHA | solution nmr | B | — | — |
| 6C1A | MBD2 in complex with methylated DNA | x-ray diffraction | A, B, E, F | UNX | 6 (best 0.61) |
| 6C1A | MBD2 in complex with methylated DNA | x-ray diffraction | A, B, E, F | UNX | — |
| 6C1T | MBD2 in complex with a partially methylated DNA | x-ray diffraction | A, D | SO4, UNX | 2 (best 0.61) |
| 6C1T | MBD2 in complex with a partially methylated DNA | x-ray diffraction | A, D | SO4, UNX | — |
| 6C1U | MBD2 in complex with a deoxy-oligonucleotide | x-ray diffraction | A, B, E, F | UNX | 5 (best 0.62) |
| 6C1U | MBD2 in complex with a deoxy-oligonucleotide | x-ray diffraction | A, B, E, F | UNX | — |
| 6C1V | MBD2 in complex with double-stranded DNA | x-ray diffraction | A, B, E, F | UNX | 6 (best 0.62) |
| 6C1V | MBD2 in complex with double-stranded DNA | x-ray diffraction | A, B, E, F | UNX | — |
| 6C2F | MBD2 in complex with methylated DNA | x-ray diffraction | A, D, G, J, M, P | UNX | — |
| 6C2F | MBD2 in complex with methylated DNA | x-ray diffraction | A, D, G, J, M, P | UNX | — |
| 6CNP | Crystal structure of MBD2 complex with methylated CpG island | x-ray diffraction | A, B | CA, UNX | 5 (best 0.56) |
| 6CNP | Crystal structure of MBD2 complex with methylated cpg island | x-ray diffraction | A, B | CA, UNX | — |
| 6CNQ | MBD2 in complex with methylated DNA | x-ray diffraction | A, B | UNX | 3 (best 0.54) |
| 6CNQ | MBD2 in complex with methylated DNA | x-ray diffraction | A, B | UNX | — |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | C | — | 4 (best 0.71) |
| 7AO8 | Structure of the MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | C | — | — |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | electron microscopy | C | — | 3 (best 0.73) |
| 7AO9 | Structure of the core MTA1/HDAC1/MBD2 nurd deacetylase complex | electron microscopy | C | — | — |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | electron microscopy | C | — | 3 (best 0.72) |
| 7AOA | Structure of the extended MTA1/HDAC1/MBD2/RBBP4 nurd deacetylase complex | electron microscopy | C | — | — |
| 7MWK | Crystal structure of MBD2 with DNA | x-ray diffraction | A, B | UNX | 3 (best 0.57) |
| 7MWK | Crystal structure of MBD2 with DNA | x-ray diffraction | A, B | UNX | — |
| 7MWM | Crystal structure of MBD2 with DNA | x-ray diffraction | A, B | UNX | — |
| 7RAY | Crystal structure of MBD2 with DNA | x-ray diffraction | A | UNX | 2 (best 0.52) |
| 7RAY | Crystal structure of MBD2 with DNA | x-ray diffraction | A | UNX | — |
| Q9UBB5 | AlphaFold monomer V2.0 prediction for methyl-cpg-binding domain protein 2 (Q9UBB5) | predicted | A | — | 1 (best 0.51) |
Ligands
Experiment against prediction
- 6CNP chain A against the predicted model Q9UBB5: TM-score 0.98, RMSD 0.37 Å
- 6CNP chain A against the predicted model Q9UBB5: TM-score 0.98, RMSD 0.37 Å
- 6C1U chain A against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.50 Å
- 6C1U chain A against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.50 Å
- 6C2F chain J against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.49 Å
- 6C2F chain J against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.49 Å
- 6C2F chain D against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.52 Å
- 6C2F chain D against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.52 Å
- 6C1V chain A against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.55 Å
- 6C1V chain A against the predicted model Q9UBB5: TM-score 0.97, RMSD 0.55 Å
Elsewhere
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