UniProt Q9U6B8
Calcium release-activated calcium channel protein 1 (Q9U6B8)
Calcium release-activated calcium channel protein 1 (UniProt Q9U6B8): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9U6B8
- Protein
- Calcium release-activated calcium channel protein 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 1 record with a druggable one
Structures
13 records of Q9U6B8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4HKR | Calcium release-activated calcium (CRAC) channel ORAI | x-ray diffraction | A, B | — | — |
| 4HKR | Calcium release-activated calcium (crac) channel orai | x-ray diffraction | A, B | — | — |
| 4HKS | Calcium release-activated calcium (CRAC) channel ORAI, K163W mutant | x-ray diffraction | A, B | — | — |
| 4HKS | Calcium release-activated calcium (crac) channel orai, K163W mutant | x-ray diffraction | A, B | — | — |
| 6AKI | Calcium release-activated calcium channel protein 1, P288L mutant | x-ray diffraction | A, B, C, D, E, F, O, P, Q, R, S, T | CL | — |
| 6BBF | The crac channel orai in an open conformation; H206A gain-of-function mutation | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 6BBG | The CRAC channel Orai in an unlatched-closed conformation | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | 20 (best 0.87) |
| 6BBG | The crac channel orai in an unlatched-closed conformation | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 6BBH | The crac channel orai in an unlatched-closed conformation; K163W loss- of-function mutation | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 6BBI | The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212… | x-ray diffraction | A, B, C | — | — |
| 6BBI | The crac channel orai in an unlatched-closed conformation; K163W loss- of-function mutation; P42212… | x-ray diffraction | A, B, C | — | — |
| 7KR5 | Cryo-EM structure of the crac channel orai in an open conformation; H206A gain-of-function mutation… | electron microscopy | A, B, C, D, E, F | CA | — |
| Q9U6B8 | AlphaFold monomer V2.0 prediction for calcium release-activated calcium channel protein 1 (Q9U6B8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7KR5 chain C against the predicted model Q9U6B8: TM-score 0.91, RMSD 1.42 Å
- 7KR5 chain E against the predicted model Q9U6B8: TM-score 0.91, RMSD 1.42 Å
- 7KR5 chain A against the predicted model Q9U6B8: TM-score 0.91, RMSD 1.42 Å
- 4HKS chain A against the predicted model Q9U6B8: TM-score 0.90, RMSD 1.79 Å
- 4HKS chain A against the predicted model Q9U6B8: TM-score 0.90, RMSD 1.79 Å
- 4HKR chain A against the predicted model Q9U6B8: TM-score 0.90, RMSD 1.79 Å
- 4HKR chain A against the predicted model Q9U6B8: TM-score 0.90, RMSD 1.79 Å
- 7KR5 chain D against the predicted model Q9U6B8: TM-score 0.88, RMSD 1.82 Å
- 7KR5 chain B against the predicted model Q9U6B8: TM-score 0.88, RMSD 1.82 Å
- 7KR5 chain F against the predicted model Q9U6B8: TM-score 0.88, RMSD 1.82 Å
Elsewhere
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