MolNFT v1 · #143840 · protein
The crac channel orai in an open conformation; H206A gain-of-function mutation
6BBF · Calcium release-activated calcium channel protein 1: “The crac channel orai in an open conformation; H206A gain-of-function mutation”. X-ray diffraction, 20 pockets (best druggability 0.85). MolNFT v1 #143840 on GenesisL1: 3D…
- PDB
- 6BBF
- Type
- protein
- Length
- 3,600 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium release-activated calcium channel protein 1
- UniProt
- Q9U6B8
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 92% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Calcium release-activated calcium channel protein 1 | protein | 150 | 92% helix, 0% strand | Q9U6B8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1170 | 0.85 | 0.85 | 113 | empty |
| 2 | 752 | 0.83 | 0.86 | 65 | empty |
| 3 | 882 | 0.83 | 0.85 | 75 | empty |
| 4 | 1059 | 0.82 | 0.82 | 82 | empty |
| 5 | 969 | 0.78 | 0.79 | 87 | empty |
Interfaces
39 interfaces between chains.
- U–V · 1371 Ų buried · 3 hydrogen bonds · protein-protein
- J–K · 1355 Ų buried · 1 hydrogen bond · protein-protein
- S–T · 1344 Ų buried · 1 hydrogen bond · protein-protein
- M–N · 1335 Ų buried · 2 hydrogen bonds · protein-protein
- G–H · 1331 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6BBF · The CRAC channel Orai in an open conformation; H206A gain-of-function mutation · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U6B8
- Elsewhere: RCSB PDB 6BBF · PDBe 6BBF · UniProt Q9U6B8
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