UniProt Q9NYY3
Serine/threonine-protein kinase PLK2 (Q9NYY3)
Serine/threonine-protein kinase PLK2 (UniProt Q9NYY3), EC 2.7.11.21: 14 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NYY3
- Protein
- Serine/threonine-protein kinase PLK2
- EC
- 2.7.11.21
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 42 · 15 records with a druggable one
Structures
15 records of Q9NYY3 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4I5M | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein… | x-ray diffraction | A | R78 | 1 (best 0.66) |
| 4I5M | Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce -synuclein… | x-ray diffraction | A | R78 | 1 (best 0.66) |
| 4I5P | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein… | x-ray diffraction | A | 1D1 | 1 (best 0.65) |
| 4I5P | Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce -synuclein… | x-ray diffraction | A | 1D1 | 1 (best 0.65) |
| 4I6B | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein… | x-ray diffraction | A | 11G | 1 (best 0.64) |
| 4I6B | Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce -synuclein… | x-ray diffraction | A | 11G | 1 (best 0.64) |
| 4I6F | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein… | x-ray diffraction | A | 1C7 | 2 (best 0.64) |
| 4I6F | Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce -synuclein… | x-ray diffraction | A | 1C7 | 2 (best 0.64) |
| 4I6H | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein… | x-ray diffraction | A | 1C8 | 1 (best 0.66) |
| 4I6H | Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce alpha-synuclein… | x-ray diffraction | A | 1C8 | 1 (best 0.66) |
| 4RS6 | Crystal structure of the C domain of Polo like Kinase II in Homo Sapiens | x-ray diffraction | A, B | — | 5 (best 0.65) |
| 4RS6 | Crystal structure of the C domain of polo like kinase II in homo sapiens | x-ray diffraction | A, B | — | 5 (best 0.65) |
| 4XB0 | Structure of the Plk2 polo-box domain | x-ray diffraction | A, B | PO4, CL | 6 (best 0.65) |
| 4XB0 | Structure of the PLK2 polo-box domain | x-ray diffraction | A, B | PO4, CL | 6 (best 0.65) |
| Q9NYY3 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK2 (Q9NYY3) | predicted | A | — | 8 (best 0.69) |
Ligands
- 11G · (7R)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one · in 2 records
- 1C7 · (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-phenyl-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- 1C8 · (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-[2-(1,3-thiazol-4-yl)-1H-imidazol-1-yl]-7,8-dihydropteridin-6(5H)-one · in 2 records
- 1D1 · (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-(1H-pyrrol-2-yl)-7,8-dihydropteridin-6(5H)-one · in 2 records
- CL · Chloride ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- R78 · 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 2 records
Experiment against prediction
- 4RS6 chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.07 Å
- 4RS6 chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.07 Å
- 4I5M chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.29 Å
- 4I5M chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.29 Å
- 4I5P chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.32 Å
- 4I5P chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.32 Å
- 4I6H chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.32 Å
- 4I6H chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.32 Å
- 4I6B chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.33 Å
- 4I6B chain A against the predicted model Q9NYY3: TM-score 0.97, RMSD 1.33 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.