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Ligand · 1C8

1C8 · (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-[2-(1,3-thiazol-4-yl)-1H-imidazol-1-yl]-7,8-dihydropteridin-6(5H)-one

1C8, (7R)-8-cyclopentyl-7-ethyl-5-methyl-2-[2-(1,3-thiazol-4-yl)-1H-imidazol-1-yl]-7,8-dihydropteridin-6(5H)-one (C20 H23 N7 O S, 409.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
1C8
Formula
C20 H23 N7 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

1C8 in 2 structures; the first of them:

  • 4I6H · Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce… · 1C8 A401 · binds LEU88, GLY89, LYS90, CYS96, ALA109, LYS111, VAL143, LEU159 and 8 more
  • 4I6H · Selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce… · 1C8 A401 · binds LEU88, GLY89, LYS90, CYS96, ALA109, LYS111, VAL143, LEU159 and 8 more

Residues it binds most

CYS 2, LEU 2, LYS 2, SER 2, ALA 2, ARG 2, GLU 2, GLY 2, HIS 2, PHE 2 (residue and the binding sites it lines).

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