MolNFT v1 · #106203 · protein

Crystal structure of the C domain of polo like kinase II in homo sapiens

4RS6 · SERINE/THREONINE-protein kinase PLK2: “Crystal structure of the C domain of polo like kinase II in homo sapiens”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #106203 on GenesisL1: 3D structure, binding sites and…

PDB: 4RS6
Type: protein
Length: 426 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PLK2
EC: 2.7.11.21
UniProt: Q9NYY3
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SERINE/THREONINE-protein kinase PLK2 (EC 2.7.11.21)	protein	213	26% helix, 32% strand	Q9NYY3

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	397	0.65	0.78	46	empty
2	115	0.45	0.78	16	empty
3	90	0.44	0.79	17	empty
4	107	0.42	0.77	18	empty
5	77	0.34	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 929 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4RS6 · Crystal structure of the C domain of Polo like Kinase II in Homo Sapiens · the same entry in another collection · chain A against A, TM-score 1.00
Q9NYY3 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK2 (Q9NYY3) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NYY3
Elsewhere: RCSB PDB 4RS6 · PDBe 4RS6 · UniProt Q9NYY3

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