UniProt Q9NXL6
SID1 transmembrane family member 1 (Q9NXL6)
SID1 transmembrane family member 1 (UniProt Q9NXL6), EC 2.1.1.375, 2.7.7.48: 13 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 248 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9NXL6
- Protein
- SID1 transmembrane family member 1
- EC
- 2.1.1.375, 2.7.7.48, 2.7.7.88
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 248 · 14 records with a druggable one
Structures
14 records of Q9NXL6 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8J6M | SIDT1 protein | electron microscopy | B, A | CLR, ZN, NA, OLA | 15 (best 0.86) |
| 8JUL | Cryo-EM structure of SIDT1 in complex with phosphatidic acid | electron microscopy | A, B | ZN, PX2 | 20 (best 0.87) |
| 8JUN | Cryo-EM structure of SIDT1 E555Q mutant | electron microscopy | A, B | ZN, POV | 20 (best 0.86) |
| 8K13 | SID1 transmembrane family member 1 | electron microscopy | A, B | NAG | 20 (best 0.86) |
| 8K1B | SID1 transmembrane family member 1 | electron microscopy | A, B | NAG | 6 (best 0.85) |
| 8K1D | SID1 transmembrane family member 1 | electron microscopy | A, B | — | 14 (best 0.85) |
| 8KCW | Cryo-EM structure of human SIDT1 bound to cholesterol | electron microscopy | A, C | NAG, ZN, CLR | 20 (best 0.86) |
| 8KCX | Cryo-EM structure of human SIDT1 | electron microscopy | A, C | NAG, ZN | 17 (best 0.86) |
| 8V38 | Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) | electron microscopy | A, B | — | 20 (best 0.89) |
| 8WOQ | Cryo-EM structure of human SIDT1 protein with C1 symmetry at neutral pH | electron microscopy | A, B | NAG, ZN, CA, CLR, OLA, SPL | 20 (best 0.87) |
| 8WOR | Cryo-EM structure of human SIDT1 protein with C2 symmetry at neutral pH | electron microscopy | A, B | NAG, ZN, CA, CLR, OLA, SPL | 20 (best 0.87) |
| 8WOS | Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH | electron microscopy | A, B | NAG, CLR, ZN | 20 (best 0.84) |
| 8WOT | Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH | electron microscopy | A, B | NAG, CLR, ZN | 20 (best 0.85) |
| Q9NXL6 | AlphaFold monomer V2.0 prediction for SID1 transmembrane family member 1 (Q9NXL6) | predicted | A | — | 16 (best 0.79) |
Ligands
- ZN · Zinc ion · in 9 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- CLR · Cholesterol · in 6 records
- OLA · Oleic acid · in 3 records
- CA · Calcium ion · in 2 records
- SPL · Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide · in 2 records
- NA · Sodium ion · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
- PX2 · 1,2-dilauroyl-sn-glycero-3-phosphate · in 1 record
Experiment against prediction
- 8J6M chain B against the predicted model Q9NXL6: TM-score 0.97, RMSD 1.65 Å
- 8K1B chain A against the predicted model Q9NXL6: TM-score 0.97, RMSD 1.19 Å
- 8KCW chain A against the predicted model Q9NXL6: TM-score 0.96, RMSD 1.81 Å
- 8K13 chain A against the predicted model Q9NXL6: TM-score 0.95, RMSD 2.01 Å
- 8WOT chain A against the predicted model Q9NXL6: TM-score 0.95, RMSD 2.09 Å
- 8WOS chain A against the predicted model Q9NXL6: TM-score 0.95, RMSD 2.11 Å
- 8JUN chain A against the predicted model Q9NXL6: TM-score 0.94, RMSD 2.28 Å
- 8KCX chain A against the predicted model Q9NXL6: TM-score 0.93, RMSD 2.72 Å
- 8K1D chain A against the predicted model Q9NXL6: TM-score 0.92, RMSD 2.05 Å
- 8JUL chain A against the predicted model Q9NXL6: TM-score 0.91, RMSD 2.97 Å
Elsewhere
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