UniProt Q9NTG7
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Q9NTG7)
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (UniProt Q9NTG7), EC 2.3.1.286, 3.5.1.-: 69 experimental structures on GenesisL1, 16 ligands bound, 98 pockets. Binding sites, pockets, druggability and 3D structures in…
- UniProt
- Q9NTG7
- Protein
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial
- EC
- 2.3.1.286, 3.5.1.-
- Experimental structures
- 69
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 98 · 13 records with a druggable one
Structures
69 records of Q9NTG7 in the MolNFT archive: 69 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GLR | Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide | x-ray diffraction | A | — | — |
| 3GLR | Crystal structure of human SIRT3 with acetyl-lysine ACECS2 peptide | x-ray diffraction | A | — | — |
| 3GLS | Crystal Structure of Human SIRT3 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3GLS | Crystal structure of human SIRT3 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3GLT | Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl… | x-ray diffraction | A | — | — |
| 3GLT | Crystal structure of human SIRT3 with adpr bound to the ACECS2 peptide containing a thioacetyl… | x-ray diffraction | A | — | — |
| 3GLU | Crystal Structure of Human SIRT3 with AceCS2 peptide | x-ray diffraction | A | — | — |
| 3GLU | Crystal structure of human SIRT3 with ACECS2 peptide | x-ray diffraction | A | — | — |
| 4BN4 | Structure of human SIRT3 in complex with ADP-ribose | x-ray diffraction | A | — | — |
| 4BN4 | Structure of human SIRT3 in complex with ADP-ribose | x-ray diffraction | A | — | — |
| 4BN5 | Structure of human SIRT3 in complex with SRT1720 inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4BN5 | Structure of human SIRT3 in complex with SRT1720 inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4BV3 | Crystal structure of SIRT3 in complex with the inhibitor ex-527 and NAD | x-ray diffraction | A | — | — |
| 4BV3 | Crystal structure of SIRT3 in complex with the inhibitor ex-527 and NAD | x-ray diffraction | A | — | — |
| 4BVB | Crystal structure of human SIRT3 in complex with the inhibitor ex-527 and ADP-ribose | x-ray diffraction | A | — | — |
| 4BVB | Crystal structure of human SIRT3 in complex with the inhibitor ex-527 and ADP-ribose | x-ray diffraction | A | — | — |
| 4BVE | Crystal structure of human SIRT3 in complex with thioalkylimidate formed from thio-acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVE | Crystal structure of human SIRT3 in complex with thioalkylimidate formed from thio-acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVF | Crystal structure of human SIRT3 in complex with thioalkylimidate formed from thio-acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVF | Crystal structure of human SIRT3 in complex with thioalkylimidate formed from thio-acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVG | Crystal structure of human SIRT3 in complex with native alkylimidate formed from acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVG | Crystal structure of human SIRT3 in complex with native alkylimidate formed from acetyl-lysine… | x-ray diffraction | A | — | — |
| 4BVH | Crystal structure of human SIRT3 in complex with the inhibitor ex-527 and 2'-O-acetyl-ADP-ribose | x-ray diffraction | A, B, C | — | — |
| 4BVH | Crystal structure of human SIRT3 in complex with the inhibitor ex-527 and 2'-O-acetyl-ADP-ribose | x-ray diffraction | A, B, C | — | — |
| 4C78 | Complex of human Sirt3 with Bromo-Resveratrol and ACS2 peptide | x-ray diffraction | A | — | — |
| 4C78 | Complex of human SIRT3 with bromo-resveratrol and ACS2 peptide | x-ray diffraction | A | — | — |
| 4C7B | Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide | x-ray diffraction | A | — | — |
| 4C7B | Complex of human SIRT3 with bromo-resveratrol and fluor-de-lys peptide | x-ray diffraction | A | — | — |
| 4FVT | Human SIRT3 bound to Ac-ACS peptide and Carba-NAD | x-ray diffraction | A | — | — |
| 4FVT | Human SIRT3 bound to ac-acs peptide and carba-NAD | x-ray diffraction | A | — | — |
| 4FZ3 | Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin | x-ray diffraction | A | — | — |
| 4FZ3 | Crystal structure of SIRT3 in complex with acetyl P53 peptide coupled with 4-amino-7-methylcoumarin | x-ray diffraction | A | — | — |
| 4HD8 | Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol | x-ray diffraction | A | — | — |
| 4HD8 | Crystal structure of human SIRT3 in complex with fluor-de-lys peptide and piceatannol | x-ray diffraction | A | — | — |
| 4JSR | Crystal Structure of human SIRT3 with ELT inhibitor 11c… | x-ray diffraction | A | — | — |
| 4JSR | Crystal structure of human SIRT3 with elt inhibitor 11C [N-{2-[1-(6… | x-ray diffraction | A | — | — |
| 4JT8 | Crystal Structure of human SIRT3 with ELT inhibitor 28… | x-ray diffraction | A | — | — |
| 4JT8 | Crystal structure of human SIRT3 with elt inhibitor 28 [4-(4-{2-[(2,2… | x-ray diffraction | A | — | — |
| 4JT9 | Crystal Structure of human SIRT3 with ELT inhibitor 3… | x-ray diffraction | A | — | — |
| 4JT9 | Crystal structure of human SIRT3 with elt inhibitor 3 [14-(4-{2… | x-ray diffraction | A | — | — |
| 4O8Z | Crystal structure of human SIRT3 in complex with compound… | x-ray diffraction | A | — | — |
| 4O8Z | Crystal structure of human SIRT3 in complex with compound (2… | x-ray diffraction | A | — | — |
| 5BWN | Crystal structure of SIRT3 with a H3K9 peptide containing a myristoyl lysine | x-ray diffraction | A | — | — |
| 5BWO | Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide | x-ray diffraction | A | PLM, ZN | 2 (best 0.82) |
| 5BWO | Crystal structure of human SIRT3 in complex with a palmitoyl H3K9 peptide | x-ray diffraction | A | — | — |
| 5D7N | Crystal structure of human SIRT3 at an improved resolution | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5H4D | Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride | x-ray diffraction | A, H | ZN, MG, BBI, NAD, MCM | — |
| 5H4D | Crystal structure of HSIRT3 in complex with a specific agonist amiodarone hydrochloride | x-ray diffraction | A, H | — | — |
| 5Y4H | Human SIRT3 in complex with halistanol sulfate | x-ray diffraction | A | ZN, 8QF | — |
| 5Y4H | Human SIRT3 in complex with halistanol sulfate | x-ray diffraction | A | ZN, 8QF | — |
| 5YTK | Crystal structure of SIRT3 bound to a leucylated AceCS2 | x-ray diffraction | A, B, C, D, E, F | ZN, LEU, LYS | 20 (best 0.77) |
| 5YTK | Crystal structure of SIRT3 bound to a leucylated ACECS2 | x-ray diffraction | A, B, C, D, E, F | ZN | — |
| 5Z93 | Crystal structure of SIRT3 in complex with H3K9BHB peptide | x-ray diffraction | A | ZN | — |
| 5Z94 | Crystal Structure of SIRT3 in complex with H3K4bhb peptide | x-ray diffraction | A, B | ZN, SO4 | 6 (best 0.78) |
| 5Z94 | Crystal structure of SIRT3 in complex with H3K4BHB peptide | x-ray diffraction | A, B | ZN, SO4 | — |
| 5ZGC | Crystal Structure of SIRT3 in complex with H4K16bhb peptide | x-ray diffraction | A, B, C, D, E, F | ZN | 20 (best 0.82) |
| 5ZGC | Crystal structure of SIRT3 in complex with H4K16BHB peptide | x-ray diffraction | A, B, C, D, E, F | ZN | — |
| 6ISO | Human SIRT3 Recognizing H3K4cr | x-ray diffraction | A, B, E, G, I, K | ZN, CRD | — |
| 6ISO | Human SIRT3 recognizing H3K4CR | x-ray diffraction | A, B, E, G, I, K | ZN, CRD | — |
| 8BBK | Crystal structure of human Sirt3 in complex with a fragment of the human AROS protein | x-ray diffraction | A, B, C, D, E, F | ZN | 20 (best 0.72) |
9 records more on the page itself.
Ligands
- ZN · Zinc ion · in 22 records
- 2OP · (2S)-2-hydroxypropanoic acid · in 2 records
- 8QF · [(2~{S},3~{S},5~{S},6~{S},8~{S},9~{S},10~{R},13~{R}, 14~{R},17~{R})-17-[(2~{R})-6,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3-disulfooxy-2,3,4,5,6,7,8,9,11,12, 14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-6-yl] hydrogen sulfate · in 2 records
- CNA · Carba-nicotinamide-adenine-dinucleotide · in 2 records
- CRD · (2E)-but-2-enal · in 2 records
- SO4 · Sulfate ion · in 2 records
- Y4T · (1P)-3',5-di(prop-2-en-1-yl)[1,1'-biphenyl]-2,4'-diol · in 2 records
- 5I7 · (phenylmethyl) ~{N}-[(2~{S})-6-[[(2~{R},3~{a}~{R},5~{R},6~{R},6~{a}~{R})-5-[[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-6-oxidanyl-2-tridecyl-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]oxathiol-2-yl]amino]-1-oxidanylidene-1-[2-(triethyl-$l^{4}-azanyl)ethylamino]hexan-2-yl]carbamate · in 1 record
- 5IA · 2-{[(2S)-6-[(Z)-(1-{[(2R,3R,4R,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-4-hydroxy-2-sulfanyloxolan-3-yl]oxy}tetradecylidene)amino]-2-{[(benzyloxy)carbonyl]amino}hexanoyl]amino}-N,N,N-triethylethan-1-aminium (non-preferred name) · in 1 record
- BBI · (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone · in 1 record
- LEU · Leucine · in 1 record
- LYS · Lysine · in 1 record
- MCM · 7-amino-4-methyl-chromen-2-one · in 1 record
- MG · Magnesium ion · in 1 record
- NAD · Nicotinamide-adenine-dinucleotide · in 1 record
- PLM · Palmitic acid · in 1 record
Elsewhere
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