UniProt Q9NRR4
Ribonuclease 3 (Q9NRR4)
Ribonuclease 3 (UniProt Q9NRR4), EC 3.1.26.3: 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NRR4
- Protein
- Ribonuclease 3
- EC
- 3.1.26.3
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 38 · 2 records with a druggable one
Structures
12 records of Q9NRR4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KHX | Drosha double-stranded RNA binding motif | solution nmr | A | — | — |
| 2KHX | Drosha double-stranded RNA binding motif | solution nmr | A | — | — |
| 2NA2 | Drosha quad mutant double-stranded RNA binding competent | solution nmr | A | — | — |
| 2NA2 | Drosha quad mutant double-stranded RNA binding competent | solution nmr | A | — | — |
| 5B16 | X-ray structure of drosha in complex with the C-terminal tail of DGCR8. | x-ray diffraction | A | — | — |
| 6LXD | Pri-miRNA bound DROSHA-DGCR8 complex | electron microscopy | A | ZN | — |
| 6LXD | Pri-miRNA bound drosha-DGCR8 complex | electron microscopy | A | ZN | — |
| 6LXE | DROSHA-DGCR8 complex | electron microscopy | A | ZN | 20 (best 0.82) |
| 6LXE | Drosha-DGCR8 complex | electron microscopy | A | ZN | — |
| 6V5B | Human drosha and DGCR8 in complex with primary microrna (MP/RNA complex) - active state | electron microscopy | A | ZN, CA | — |
| 6V5C | Human drosha and DGCR8 in complex with primary microrna (MP/RNA complex) - partially docked state | electron microscopy | A | — | — |
| Q9NRR4 | AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q9NRR4) | predicted | A | — | 18 (best 0.87) |
Ligands
Experiment against prediction
- 6V5B chain A against the predicted model Q9NRR4: TM-score 0.98, RMSD 1.66 Å
- 6LXD chain A against the predicted model Q9NRR4: TM-score 0.97, RMSD 1.76 Å
- 6LXD chain A against the predicted model Q9NRR4: TM-score 0.97, RMSD 1.76 Å
- 6LXE chain A against the predicted model Q9NRR4: TM-score 0.90, RMSD 2.65 Å
- 6LXE chain A against the predicted model Q9NRR4: TM-score 0.90, RMSD 2.65 Å
- 5B16 chain A against the predicted model Q9NRR4: TM-score 0.89, RMSD 2.33 Å
- 6V5C chain A against the predicted model Q9NRR4: TM-score 0.82, RMSD 4.00 Å
- 2NA2 chain A against the predicted model Q9NRR4: TM-score 0.68, RMSD 3.28 Å
- 2NA2 chain A against the predicted model Q9NRR4: TM-score 0.68, RMSD 3.28 Å
- 2KHX chain A against the predicted model Q9NRR4: TM-score 0.59, RMSD 3.17 Å
Elsewhere
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