MolNFT v1 · #45676 · protein

Drosha quad mutant double-stranded RNA binding competent

2NA2 · Ribonuclease 3: “Drosha quad mutant double-stranded RNA binding competent”. Solution nmr, 2 pockets (best druggability 0.57). MolNFT v1 #45676 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2NA2
Type: protein
Length: 82 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease 3
EC: 3.1.26.3
UniProt: Q9NRR4
Pockets: 2 · best druggability 0.57

Structure

solution nmr · 1 distinct chain · 29% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease 3 (EC 3.1.26.3)	protein	82	29% helix, 26% strand	Q9NRR4

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.57	0.90	18	empty
2	64	0.31	0.74	14	empty

Compared structures

2NA2 · Drosha quad mutant double-stranded RNA binding competent · the same entry in another collection · chain A against A, TM-score 1.00
Q9NRR4 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q9NRR4) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NRR4
Elsewhere: RCSB PDB 2NA2 · PDBe 2NA2 · UniProt Q9NRR4

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