UniProt Q9NRF8
CTP synthase 2 (Q9NRF8)
CTP synthase 2 (UniProt Q9NRF8), EC 6.3.4.2: 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 85 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NRF8
- Protein
- CTP synthase 2
- EC
- 6.3.4.2
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 85 · 5 records with a druggable one
Structures
17 records of Q9NRF8 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V4U | Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE | x-ray diffraction | A | — | — |
| 2V4U | Human CTP synthetase 2 - glutaminase domain in complex with 5-oxo-L-norleucine | x-ray diffraction | A | — | — |
| 2VKT | Human CTP synthetase 2 - glutaminase domain | x-ray diffraction | A | — | — |
| 2VKT | Human CTP synthetase 2 - glutaminase domain | x-ray diffraction | A | — | — |
| 3IHL | Human CTPS2 crystal structure | x-ray diffraction | A, B | — | — |
| 3IHL | Human CTPS2 crystal structure | x-ray diffraction | A, B | — | — |
| 6PK4 | cryoEM structure of the substrate-bound human CTP synthase 2 filament | electron microscopy | A, B, C, D | UTP, ATP | 20 (best 0.85) |
| 6PK4 | Cryoem structure of the substrate-bound human CTP synthase 2 filament | electron microscopy | A, B, C, D | UTP, ATP | — |
| 6PK7 | cryoEM structure of the product-bound human CTP synthase 2 filament | electron microscopy | A, D, E, F | ADP, CTP | 20 (best 0.86) |
| 6PK7 | Cryoem structure of the product-bound human CTP synthase 2 filament | electron microscopy | A, D, E, F | ADP, CTP | — |
| 7MH1 | Human CTPS2 bound to CTP | electron microscopy | H, J, K, L | CTP, MG | — |
| 7MH1 | Human CTPS2 bound to CTP | electron microscopy | H, J, K, L | CTP, MG | — |
| 7MIH | Human CTPS2 bound to inhibitor R80 | electron microscopy | A, B, C, E | ZG4, UTP, GLN, MG | 20 (best 0.87) |
| 7MIH | Human CTPS2 bound to inhibitor R80 | electron microscopy | A, B, C, E | ZG4, UTP, MG | — |
| 7MII | Human CTPS2 bound to inhibitor T35 | electron microscopy | A, B, C, E | ZFY, UTP, GLN, MG | 20 (best 0.86) |
| 7MII | Human CTPS2 bound to inhibitor T35 | electron microscopy | A, B, C, E | ZFY, UTP, MG | — |
| Q9NRF8 | AlphaFold monomer V2.0 prediction for CTP synthase 2 (Q9NRF8) | predicted | A | — | 5 (best 0.68) |
Ligands
- MG · Magnesium ion · in 6 records
- UTP · Uridine 5'-triphosphate · in 6 records
- CTP · Cytidine-5'-triphosphate · in 4 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- GLN · Glutamine · in 2 records
- ZFY · 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide · in 2 records
- ZG4 · N-(1-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}cyclopropyl)-5-(6-ethoxypyrazin-2-yl)pyridine-2-carboxamide · in 2 records
Experiment against prediction
- 7MII chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.62 Å
- 7MIH chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.66 Å
- 7MII chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.62 Å
- 7MIH chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.66 Å
- 3IHL chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.67 Å
- 3IHL chain A against the predicted model Q9NRF8: TM-score 0.99, RMSD 0.67 Å
- 2VKT chain A against the predicted model Q9NRF8: TM-score 0.97, RMSD 1.07 Å
- 2VKT chain A against the predicted model Q9NRF8: TM-score 0.97, RMSD 1.07 Å
- 7MH1 chain H against the predicted model Q9NRF8: TM-score 0.97, RMSD 1.67 Å
- 7MH1 chain H against the predicted model Q9NRF8: TM-score 0.97, RMSD 1.67 Å
Elsewhere
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