MolNFT v1 · #51890 · protein

Human CTP synthetase 2 - glutaminase domain

2VKT · CTP synthase 2: “Human CTP synthetase 2 - glutaminase domain”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #51890 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VKT
Type: protein
Length: 252 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CTP synthase 2
EC: 6.3.4.2
UniProt: Q9NRF8
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CTP synthase 2 (EC 6.3.4.2)	protein	252	36% helix, 29% strand	Q9NRF8

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.42	0.77	22	empty
2	51	0.41	0.82	13	empty
3	53	0.27	0.74	13	empty

Compared structures

2VKT · Human CTP synthetase 2 - glutaminase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9NRF8 · AlphaFold monomer V2.0 prediction for CTP synthase 2 (Q9NRF8) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NRF8
Elsewhere: RCSB PDB 2VKT · PDBe 2VKT · UniProt Q9NRF8

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