UniProt Q9NPI1
Bromodomain-containing protein 7 (Q9NPI1)
Bromodomain-containing protein 7 (UniProt Q9NPI1): 14 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NPI1
- Protein
- Bromodomain-containing protein 7
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 7 · 3 records with a druggable one
Structures
15 records of Q9NPI1 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I7K | Solution Structure of the Bromodomain of Human BRD7 Protein | solution nmr | A | — | — |
| 2I7K | Solution structure of the bromodomain of human BRD7 protein | solution nmr | A | — | — |
| 5MQ1 | Crystal structure of the BRD7 bromodomain in complex with BI-9564 | x-ray diffraction | A | 5U6, ZN, CL | 1 (best 0.52) |
| 5MQ1 | Crystal structure of the BRD7 bromodomain in complex with bi-9564 | x-ray diffraction | A | 5U6, ZN, CL | — |
| 6PPA | Crystal structure of the unliganded bromodomain of human BRD7 | x-ray diffraction | A | PO4 | — |
| 6V0Q | Crystal structure of the bromodomain of human BRD7 bound to TG003 | x-ray diffraction | A, B, C, D | PO4, CL, EAE | — |
| 6V16 | Crystal structure of the bromodomain of human BRD7 bound to TP472 | x-ray diffraction | A, B | QMG | 3 (best 0.69) |
| 6V16 | Crystal structure of the bromodomain of human BRD7 bound to TP472 | x-ray diffraction | A, B | QMG | — |
| 6V17 | Crystal structure of the bromodomain of human BRD7 bound to I-BRD9 | x-ray diffraction | A, B | CL, H1B | 3 (best 0.64) |
| 6V17 | Crystal structure of the bromodomain of human BRD7 bound to I-BRD9 | x-ray diffraction | A, B | CL, H1B | — |
| 6V1E | Crystal structure of the bromodomain of human BRD7 bound to BI7273 | x-ray diffraction | A | 5SW | — |
| 6V1F | Crystal structure of the bromodomain of human BRD7 bound to BI9564 | x-ray diffraction | A | 5U6 | — |
| 6V1H | Crystal structure of the bromodomain of human BRD7 bound to bromosporine | x-ray diffraction | A | BMF | — |
| 7VDV | The overall structure of human chromatin remodeling pbaf-nucleosome complex | electron microscopy | T | — | — |
| Q9NPI1 | AlphaFold monomer V2.0 prediction for bromodomain-containing protein 7 (Q9NPI1) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 5 records
- 5U6 · 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one · in 3 records
- H1B · N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide · in 2 records
- PO4 · Phosphate ion · in 2 records
- QMG · 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide · in 2 records
- ZN · Zinc ion · in 2 records
- 5SW · 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one · in 1 record
- BMF · Bromosporine · in 1 record
- EAE · (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one · in 1 record
Experiment against prediction
- 6V0Q chain B against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.34 Å
- 6V0Q chain C against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.34 Å
- 6V1F chain A against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.35 Å
- 6V1H chain A against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.36 Å
- 6V16 chain B against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.38 Å
- 6V16 chain B against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.38 Å
- 6V0Q chain D against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.42 Å
- 6V0Q chain A against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.53 Å
- 6V16 chain A against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.49 Å
- 6V16 chain A against the predicted model Q9NPI1: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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