UniProt Q9KVG7
Cyclic GMP-AMP synthase (Q9KVG7)
Cyclic GMP-AMP synthase (UniProt Q9KVG7), EC 2.7.7.-: 24 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9KVG7
- Protein
- Cyclic GMP-AMP synthase
- EC
- 2.7.7.-
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 9 · 2 records with a druggable one
Structures
25 records of Q9KVG7 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4TXY | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | x-ray diffraction | A, B | — | — |
| 4TXY | Crystal structure of vibrio cholerae dncv cyclic AMP-gmp synthase, a prokaryotic cgas homolog | x-ray diffraction | A, B | — | — |
| 4TXZ | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable… | x-ray diffraction | A, B | — | — |
| 4TXZ | Crystal structure of vibrio cholerae dncv cyclic AMP-gmp synthase in complex with nonhydrolyzable… | x-ray diffraction | A, B | — | — |
| 4TY0 | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear… | x-ray diffraction | A, B | — | — |
| 4TY0 | Crystal structure of vibrio cholerae dncv cyclic AMP-gmp synthase in complex with linear… | x-ray diffraction | A, B | — | — |
| 4U03 | Structure of the vibrio cholerae di-nucleotide cyclase (DncV) in complex with GTP and 5MTHFGLU2 | x-ray diffraction | A, B | — | — |
| 4U03 | Structure of the vibrio cholerae di-nucleotide cyclase (dncv) in complex with GTP and 5MTHFGLU2 | x-ray diffraction | A, B | — | — |
| 4U0L | Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D131A-D133A | x-ray diffraction | A, B | — | — |
| 4U0L | Structure of the vibrio cholerae di-nucleotide cyclase (dncv) mutant D131A-D133A | x-ray diffraction | A, B | — | — |
| 4U0M | Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D193N in complex with ATP, GTP… | x-ray diffraction | A, B | — | — |
| 4U0M | Structure of the vibrio cholerae di-nucleotide cyclase (dncv) mutant D193N in complex with ATP, GTP… | x-ray diffraction | A, B | — | — |
| 4U0N | Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop | x-ray diffraction | A, B | — | — |
| 4U0N | Structure of the vibrio cholerae di-nucleotide cyclase (dncv) deletion mutant D-loop | x-ray diffraction | A, B | — | — |
| 4XJ1 | Crystal structure of Vibrio cholerae DncV apo form | x-ray diffraction | A | — | 2 (best 0.67) |
| 4XJ1 | Crystal structure of vibrio cholerae dncv apo form | x-ray diffraction | A | — | — |
| 4XJ3 | Crystal structure of Vibrio cholerae DncV GTP bound form | x-ray diffraction | A | — | — |
| 4XJ3 | Crystal structure of vibrio cholerae dncv GTP bound form | x-ray diffraction | A | — | — |
| 4XJ4 | Crystal structure of Vibrio cholerae DncV 3'-deoxy ATP bound form | x-ray diffraction | A | — | — |
| 4XJ4 | Crystal structure of vibrio cholerae dncv 3'-deoxy ATP bound form | x-ray diffraction | A | — | — |
| 4XJ5 | Crystal structure of Vibrio cholerae DncV 3'-deoxy GTP bound form | x-ray diffraction | A | — | — |
| 4XJ5 | Crystal structure of vibrio cholerae dncv 3'-deoxy GTP bound form | x-ray diffraction | A | — | — |
| 5GO3 | Crystal structure of a di-nucleotide cyclase Vibrio mutant | x-ray diffraction | A, B | — | 7 (best 0.70) |
| 5GO3 | Crystal structure of a di-nucleotide cyclase vibrio mutant | x-ray diffraction | A, B | — | — |
| Q9KVG7 | AlphaFold monomer V2.0 prediction for cyclic gmp-AMP synthase (Q9KVG7) | predicted | A | — | — |
Experiment against prediction
- 4TY0 chain B against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.42 Å
- 4TY0 chain B against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.42 Å
- 4TY0 chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.46 Å
- 4TY0 chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.46 Å
- 4TXZ chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.45 Å
- 4TXZ chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.45 Å
- 4TXZ chain B against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.47 Å
- 4TXZ chain B against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.47 Å
- 4TXY chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.48 Å
- 4TXY chain A against the predicted model Q9KVG7: TM-score 1.00, RMSD 0.48 Å
Elsewhere
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