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Ligand · TLL

TLL · N-[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-glutamic acid

TLL, N-[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-glutamic acid (C25 H32 N8 O9, 588.6 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries).…

Component
TLL
Formula
C25 H32 N8 O9
Class
ligand
Structures
6
PDB entries
3

Binding sites

TLL in 6 structures; the first of them:

  • 4U03 · Structure of the vibrio cholerae di-nucleotide cyclase (DncV) in complex with GTP and… · TLL A505 · binds ARG36, ARG40, ARG44, ARG108, PHE109, TRP110, THR111, GLN116 and 13 more
  • 4U0M · Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D193N in complex… · TLL A504 · binds ARG36, ARG40, ARG44, PRO107, ARG108, PHE109, TRP110, THR111 and 15 more
  • 4U0N · Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop · TLL A402 · binds LYS37, ARG40, LEU41, ARG44, THR106, PRO107, ARG108, PHE109 and 8 more
  • 4U03 · Structure of the vibrio cholerae di-nucleotide cyclase (dncv) in complex with GTP and… · TLL A505 · binds ARG36, ARG40, ARG44, ARG108, PHE109, TRP110, THR111, GLN116 and 13 more
  • 4U0M · Structure of the vibrio cholerae di-nucleotide cyclase (dncv) mutant D193N in complex… · TLL A504 · binds ARG36, ARG40, ARG44, PRO107, ARG108, PHE109, TRP110, THR111 and 15 more
  • 4U0N · Structure of the vibrio cholerae di-nucleotide cyclase (dncv) deletion mutant D-loop · TLL A402 · binds LYS37, ARG40, LEU41, ARG44, THR106, PRO107, ARG108, PHE109 and 8 more

Residues it binds most

ARG 10, ASP 10, PHE 10, TYR 10, LYS 10, PRO 10, GLN 6, THR 10, ILE 10, LEU 10 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • GTP · Guanosine-5'-triphosphate
  • ATP · Adenosine-5'-triphosphate

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