UniProt Q9KEI9
Ribonuclease H (Q9KEI9)
Ribonuclease H (UniProt Q9KEI9), EC 3.1.26.4: 180 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9KEI9
- Protein
- Ribonuclease H
- EC
- 3.1.26.4
- Experimental structures
- 180
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 70 · 6 records with a druggable one
Structures
181 records of Q9KEI9 in the MolNFT archive: 180 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZBF | Crystal structure of B. halodurans RNase H catalytic domain mutant D132N | x-ray diffraction | A | — | — |
| 1ZBF | Crystal structure of B. halodurans RNase H catalytic domain mutant D132N | x-ray diffraction | A | — | — |
| 1ZBI | Bacillus halodurans RNase H catalytic domain mutant D132N in complex with 12-mer RNA/DNA hybrid | x-ray diffraction | A, B | — | — |
| 1ZBI | Bacillus halodurans RNase H catalytic domain mutant D132N in complex with 12-mer RNA/DNA hybrid | x-ray diffraction | A, B | — | — |
| 2G8F | B. halodurans RNase H catalytic domain E188A mutant in complex with Mg2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8F | B. halodurans RNase H catalytic domain E188A mutant in complex with MG2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8H | B. halodurans RNase H catalytic domain D192N mutant in complex with Mg2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8H | B. halodurans RNase H catalytic domain D192N mutant in complex with MG2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8I | B. halodurans RNase H catalytic domain D192N mutant in complex with Mn2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8I | B. halodurans RNase H catalytic domain D192N mutant in complex with MN2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8K | B. halodurans RNase H catalytic domain D192N mutant in complex with Ca2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8K | B. halodurans RNase H catalytic domain D192N mutant in complex with CA2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8U | B. halodurans RNase H catalytic domain D132N mutant in complex with Mg2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8U | B. halodurans RNase H catalytic domain D132N mutant in complex with MG2+ and RNA/DNA hybrid (non-P… | x-ray diffraction | A | — | — |
| 2G8V | B. halodurans RNase H catalytic domain E188A mutant in complex with Mg2+ and RNA/DNA hybrid… | x-ray diffraction | A | — | — |
| 2G8V | B. halodurans RNase H catalytic domain E188A mutant in complex with MG2+ and RNA/DNA hybrid… | x-ray diffraction | A | — | — |
| 2G8W | B. halodurans RNase H catalytic domain E188A mutant in complex with Ca2+ and RNA/DNA hybrid | x-ray diffraction | A | — | — |
| 2G8W | B. halodurans RNase H catalytic domain E188A mutant in complex with CA2+ and RNA/DNA hybrid | x-ray diffraction | A | — | — |
| 2R7Y | Selenium Derivatized RNA/DNA Hybrid in complex with RNase H CATALYTIC DOMAIN MUTANT D132N | x-ray diffraction | A | — | — |
| 2R7Y | Selenium derivatized RNA/DNA hybrid in complex with RNase H catalytic domain mutant D132N | x-ray diffraction | A | — | — |
| 3D0P | Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a… | x-ray diffraction | A, C | — | — |
| 3D0P | Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a… | x-ray diffraction | A, C | — | — |
| 3EY1 | A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High… | x-ray diffraction | A | — | — |
| 3EY1 | A conformational transition in the structure of a 2'-thiomethyl- modified DNA visualized at high… | x-ray diffraction | A | — | — |
| 3I8D | The Pairing Geometry of the Hydrophobic Thymine Analog 2,4-Difluorotoluene in Duplex DNA as… | x-ray diffraction | A, C | — | — |
| 3I8D | The pairing geometry of the hydrophobic thymine analog 2,4- difluorotoluene in duplex DNA as… | x-ray diffraction | A, C | — | — |
| 3TWH | Selenium Derivatized RNA/DNA Hybrid in complex with RNase H Catalytic Domain D132N Mutant | x-ray diffraction | A | — | — |
| 3TWH | Selenium derivatized RNA/DNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | — | — |
| 3ULD | High resolution structure of DNA/RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | — | — |
| 3ULD | High resolution structure of DNA/RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | — | — |
| 4HTU | Structure of 5-chlorouracil modified A:U base pair | x-ray diffraction | A, B | — | — |
| 4HTU | Structure of 5-chlorouracil modified A:U base pair | x-ray diffraction | A, B | — | — |
| 4HUE | Structure of 5-chlorouracil modified G:U base pair | x-ray diffraction | A, B | — | — |
| 4HUE | Structure of 5-chlorouracil modified G:U base pair | x-ray diffraction | A, B | — | — |
| 4HUF | Structure of 5-chlorouracil modified A:U base pair | x-ray diffraction | A, B | — | — |
| 4HUF | Structure of 5-chlorouracil modified A:U base pair | x-ray diffraction | A, B | — | — |
| 4HUG | Structure of 5-chlorouracil modified A:U base pairs | x-ray diffraction | A, B | — | — |
| 4HUG | Structure of 5-chlorouracil modified A:U base pairs | x-ray diffraction | A, B | — | — |
| 4OPJ | Bh-RNaseH:tcdA-DNA complex | x-ray diffraction | A, C | — | — |
| 4OPJ | Bh-RNASEH:TCDA-DNA complex | x-ray diffraction | A, C | — | — |
| 4OPK | Bh-RNaseH:2'-SMe-DNA complex | x-ray diffraction | A, C | — | — |
| 4OPK | Bh-RNASEH:2'-sme-DNA complex | x-ray diffraction | A, C | — | — |
| 5SWM | Bacillus halodurans RNase H mutant D132N in complex with 12-mer FRNA/DNA hybrid | x-ray diffraction | A, B | NA, CL | 1 (best 0.34) |
| 5SWM | Bacillus halodurans RNase H mutant D132N in complex with 12-mer FRNA/DNA hybrid | x-ray diffraction | A, B | NA, CL | — |
| 5US2 | 2-Se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5US2 | 2-se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5USA | 5-Se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | 1 (best 0.26) |
| 5USA | 5-se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5USE | 5-Se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | 2 (best 0.34) |
| 5USE | 5-se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5USG | 5-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | 1 (best 0.27) |
| 5USG | 5-se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5VAJ | BhRNase H - amide-RNA/DNA complex | x-ray diffraction | A, B | MG | — |
| 5VAJ | Bhrnase H - amide-RNA/DNA complex | x-ray diffraction | A, B | MG | — |
| 5W7N | 2-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5W7N | 2-se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5W7O | 2-Se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | 1 (best 0.27) |
| 5W7O | 2-se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | x-ray diffraction | A | MG | — |
| 5WJR | High resolution native hexamer DNA and RNA hybrid in complex with RNase H catalytic domain D132N… | x-ray diffraction | A | MG | 2 (best 0.34) |
| 5WJR | High resolution native hexamer DNA and RNA hybrid in complex with RNase H catalytic domain D132N… | x-ray diffraction | A | MG | — |
121 records more on the page itself.
Ligands
- MG · Magnesium ion · in 99 records
- IOD · Iodide ion · in 92 records
- K · Potassium ion · in 88 records
- CL · Chloride ion · in 24 records
- MN · Manganese (II) ion · in 22 records
- RB · Rubidium ion · in 18 records
- NA · Sodium ion · in 9 records
- CA · Calcium ion · in 6 records
- LI · Lithium ion · in 4 records
- FWN · 2-[2-(2-ethoxyethoxy)ethoxy]ethanol · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5USE chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.19 Å
- 5USE chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.19 Å
- 2R7Y chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.19 Å
- 2R7Y chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.19 Å
- 5W7O chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.20 Å
- 5W7O chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.20 Å
- 5USG chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.20 Å
- 5USG chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.20 Å
- 6DPO chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.21 Å
- 6DPA chain A against the predicted model Q9KEI9: TM-score 1.00, RMSD 0.22 Å
Elsewhere
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